Results 101 to 110 of about 1,745,964 (294)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The backtracking survey propagation algorithm for solving random K-SAT problems
Nature Communications, 2016 The K-satisfability problem is a combinatorial discrete optimization problem, which for K=3 is NP-complete, and whose random formulation is of interest for understanding computational complexity.
Raffaele Marino +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Combinatorial optimization tolerances calculated in linear time [PDF]
For a given optimal solution to a combinatorial optimization problem, we show, under very natural conditions, the equality of the minimal values of upper and lower tolerances, where the upper tolerances are calculated for the given optimal solution and ...
Goldengorin, Boris, Sierksma, Gerard
core
, 2019 Addressing the management of water bodies that cross political, cultural, and ecological boundaries entails working with a level of complexity that requires creative, adaptive management strategies that build resilience throughout the system and allow ...
Spett, Emma J
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The Complexity of Some Combinatorial Puzzles
CoRR, 2015 We show that the decision versions of the puzzles Knossos and The Hour-Glass are complete for NP.
openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Journal of Electrical Systems and Information TechnologyThe increasing complexity of combinatorial algorithms, especially for solving NP-hard problems like the knapsack problem, has heightened the need for energy- and time-efficient computational solutions.
Bashar Bin Usman +5 more
doaj +1 more source