Results 111 to 120 of about 1,745,964 (294)
Kolmogorov Complexity as a Combinatorial Tool
Prepared as an special session invited talk at CiE ...
openaire +4 more sources
Testing BOI and BOB algorithms for solving the Winner Determination [PDF]
, 2008 Eighth International Conference on Hybrid Intelligent Systems, 2008. HIS '08. Barcelona, 10-12 September 2008Combinatorial auctions are a promising auction format for allocating radio spectrum, as well as other goods.
Sáez, Yago +9 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
BMC Bioinformatics, 2006 Background: Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial explosion of different states generated by feasible molecular species.
Kholodenko Boris N +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Learning Molecular Mixture Property Using Chemistry-Aware Graph Neural Network
PRX EnergyRecent advances in machine learning (ML) are expediting materials discovery and design. One significant challenge facing ML for materials is the expansive combinatorial space of potential materials formed by diverse constituents and their flexible ...
Hengrui Zhang (张恒睿) +5 more
doaj +1 more source
Complexity results and exact algorithms for robust knapsack problems. [PDF]
This paper studies the robust knapsack problem, for which solutions are, up to a certain point, immune to data uncertainty. We complement the works found in the literature where uncertainty affects only the profits or only the weights of the items by ...
Leus, Roel, Talla Nobibon, Fabrice
core
Teaching Complexity: The Limits of Evidence and the ‘Prospective’ Case Study [PDF]
, 2018 Policy practitioner–students in a Master of Public Policy programme in New Zealand describe many problems and processes in their work environments as ‘complex’.
Wolf, Amanda, Amanda Wolf
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