Results 201 to 210 of about 9,474,722 (291)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Parallelized contactless microfluidic dispenser with superhydrophobic nozzles for scalable combinatorial screening. [PDF]

Biomicrofluidics
Wongwiset N, Stephens ML, Quiñones-Díaz BI, Mehboudi A, Contreras LM, Sreenivasan SV.   +5 more
europepmc   +1 more source

Combinatorial designs and perfect codes

Electronic Notes in Discrete Mathematics, 2001
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Combinatorial Design Testing in Genomes with POLAR-seq

Ciurkot K, Lu X, Malyshava A, Soro L, Lees A, Gorochowski TE, Ellis T.   +6 more
europepmc   +1 more source

Translational landscape of cytokine-induced killer cell therapy: an analysis based on the Informa database. [PDF]

J Immunother Cancer
Zhang Y, Sun H, Yuan Y, Liu D, Qiao J.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Lignonaut: designing diverse combinatorial libraries for the exploration and annotation of lignin oligomer spaces. [PDF]

J Cheminform
Norberg M, Sandahl M, Spégel P.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Considerations on combination therapies for disease modification in Parkinson's. [PDF]

NPJ Parkinsons Dis
Hughes RM, Pilcicka A, Klee T, Ducotterd F, Mortiboys H, Stott SRW.   +5 more
europepmc   +1 more source