Results 221 to 230 of about 9,474,722 (291)

Constructing and characterizing trillion-scale combinatorial chemical library. [PDF]

J Cheminform
Su J, Song FV, Huang D, Liao M.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Artificial intelligence and automation in enzyme engineering: evolution, advances, and future perspectives. [PDF]

Bioresour Bioprocess
Hao K, Liu J, Tang H, Zhang Y, Sun Y, Zhang H, Wang J, Liu P, Luo J, Zhao J.   +9 more
europepmc   +1 more source

Combinatorial design of multimeric chelating peptoids for selective metal coordination. [PDF]

Chem Sci, 2019
Ricano A, Captain I, Carter KP, Nell BP, Deblonde GJ, Abergel RJ.   +5 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Machine learning-assisted high-speed combinatorial optimization with Ising machines for dynamically changing problems. [PDF]

Nat Commun
Hamakawa Y, Kashimata T, Yamasaki M, Tatsumura K.   +3 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

High-Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI-MS. [PDF]

Adv Sci (Weinh)
Breitfeld M, Dietsche CL, Born FL, Onipko I, Blaase L, Dittrich PS.   +5 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human-relevant translation. [PDF]

Animal Model Exp Med
Rafi MSH, Sarker MT, Joy FU, Shams SM, Foyez T, Mazid MA, Dewan SMR.   +6 more
europepmc   +1 more source