Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells. [PDF]
Weykopf G +3 more
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Comparing metabolic engineering scenarios using simulated design-build-test-learn-cycles. [PDF]
Van Lent P, Paz SM, Schmitz J, Abeel T.
europepmc +1 more source
The Quantum Optimization Benchmarking Library. [PDF]
Koch T +26 more
europepmc +1 more source
Pharmacogenomics for stratified antidepressant treatment in major depressive disorder: evidence, limits and a roadmap for clinical use. [PDF]
Baune BT.
europepmc +1 more source
Circumventing Ewing sarcoma tumor microenvironment resistance by IL1RAP CAR-modified TGFβ1-imprinted natural killer cells in combination with IL-15 agonist and anti-GD2 antibody. [PDF]
Luo W +14 more
europepmc +1 more source
Identification of novel reproducible combinatorial genetic risk factors for myalgic encephalomyelitis in the DecodeME patient cohort and commonalities with long COVID. [PDF]
Sardell JM +13 more
europepmc +1 more source
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Combinatorial protein libraries permit the examination of a wide range of sequences. Such methods are being used for denovo design and to investigate the determinants of protein folding. The exponentially large number of possible sequences, however, necessitates restrictions on the diversity of sequences in a combinatorial library.
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