Results 31 to 40 of about 287,386 (283)

A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity. [PDF]

PLoS ONE, 2015
The present work describes the construction and validation of a human scFv library with a novel design approach to synthetic complementarity determining region (CDR) diversification.
Xuelian Bai, Jihye Kim, Seungmin Kang, Wankyu Kim, Hyunbo Shim   +4 more
doaj   +1 more source

Application of Combinatorial Interaction Design for DC Servomotor PID Controller Tuning

Journal of Control Science and Engineering, 2014
Combinatorial optimization has been used in different research areas. It has been employed successfully in software testing fields to construct minimum set of combinations (i.e., in terms of size) which in turn represents the minimum number of test cases.
Mouayad A. Sahib, Bestoun S. Ahmed, Moayad Y. Potrus   +2 more
doaj   +1 more source

Combinatorial assembly and design of enzymes

Science, 2022
The design of structurally diverse enzymes is constrained by long-range interactions that are necessary for accurate folding. We introduce an atomistic and machine learning strategy for the combinatorial assembly and design of enzymes (CADENZ) to design fragments that combine with one another to generate diverse, low-energy structures with stable ...
Lipsh-Sokolik, R., Khersonsky, O., Schröder, S. P., de Boer, C., Hoch, S.-Y., Davies, G. J., Overkleeft, H. S., Fleishman, S. J.   +7 more
openaire   +3 more sources

Design of online combinatorial auction mechanism for urban land transfer.

PLoS ONE, 2023
With the wide application of the "Tender, Auction, and Listing" system for land in China, it is of paramount importance to establish a sound land auction mechanism so as to avoid unreasonable land allocation.
Yajuan Wang, Yan Zhang
doaj   +2 more sources

Weld sequence optimization: the use of surrogate models for solving sequential combinatorial problems

, 2005
The solution of combinatorial optimization problems usually involves the consideration of many possible design configurations. This often makes such approaches computationally expensive, especially when dealing with complex finite element models.
Bhaskar, A., Keane, A.J., Olsen, Tor M., Voutchkov, I.   +3 more
core   +1 more source

DeviceEditor visual biological CAD canvas

Journal of Biological Engineering, 2012
Background Biological Computer Aided Design (bioCAD) assists the de novo design and selection of existing genetic components to achieve a desired biological activity, as part of an integrated design-build-test cycle.
Chen Joanna, Densmore Douglas, Ham Timothy S, Keasling Jay D, Hillson Nathan J   +4 more
doaj   +1 more source

Small examples of mosaics of combinatorial designs

Examples and Counterexamples
We give the first example of a mosaic of three combinatorial designs with distinct parameters 2-(13,3,1), 2-(13,4,2), and 2-(13,6,5). Furthermore, we give examples of mosaics of 2-(9,3,2) designs that are not resolvable, thereby answering a question ...
Vedran Krčadinac
doaj   +1 more source

Rapid quantum approaches for combinatorial optimisation inspired by optimal state-transfer [PDF]

Quantum
We propose a new design heuristic to tackle combinatorial optimisation problems, inspired by Hamiltonians for optimal state-transfer. The result is a rapid approximate optimisation algorithm.
Robert J. Banks, Dan E. Browne, P.A. Warburton   +2 more
doaj   +1 more source

Demonstration of a laser powder bed fusion combinatorial sample for high-throughput microstructure and indentation characterization

Materials & Design, 2021
High-throughput experiments that use combinatorial samples with rapid measurements can be used to provide process-structure-property information at reduced time, cost, and effort.
Jordan S. Weaver, Adam L. Pintar, Carlos Beauchamp, Howie Joress, Kil-Won Moon, Thien Q. Phan   +5 more
doaj   +1 more source

Systems approaches and algorithms for discovery of combinatorial therapies

, 2009
Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks.
Agoston V, Balamurugan D, Calzolari D, Carlson JM, Greco WR, Johannesson GH, Nelander S, Segota E, Spall JC, Wadman M, Weinberg RA, Yang K   +11 more
core   +1 more source