Results 11 to 20 of about 287,386 (283)

The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective

open access: yesNature Communications, 2022
Intra-tumor heterogeneity is often associated with resistance to targeted therapy, requiring the design of combinatorial therapies. Here, based on tumor single-cell transcriptomic datasets, the authors develop a computational approach to identify optimal
Saba Ahmadi   +8 more
doaj   +1 more source

Optimum Design of PIλDμ Controller for an Automatic Voltage Regulator System Using Combinatorial Test Design. [PDF]

open access: yesPLoS ONE, 2016
Combinatorial test design is a plan of test that aims to reduce the amount of test cases systematically by choosing a subset of the test cases based on the combination of input variables.
Bestoun S Ahmed   +4 more
doaj   +1 more source

Redundancy in Key Management for WSNs

open access: yesCryptography, 2018
Security in wireless sensor networks is commonly based on symmetric encryption and requires key-management systems to establish and exchange secret keys.
Filippo Gandino   +2 more
doaj   +1 more source

Dynamical System-Based Computational Models for Solving Combinatorial Optimization on Hypergraphs

open access: yesIEEE Journal on Exploratory Solid-State Computational Devices and Circuits, 2023
The intrinsic energy minimization in dynamical systems offers a valuable tool for minimizing the objective functions of computationally challenging problems in combinatorial optimization. However, most prior works have focused on mapping such dynamics to
Mohammad Khairul Bashar   +3 more
doaj   +1 more source

On combinatorial designs with subdesigns

open access: yesDiscrete Mathematics, 1989
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rolf S. Rees, Douglas R. Stinson
openaire   +2 more sources

Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries [PDF]

open access: yes, 2003
Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries.
Bohl, M.   +6 more
core   +1 more source

Dendrogram-directed design space exploration for decision-making of a multi-objective combinatorial design problem

open access: yesNihon Kikai Gakkai ronbunshu, 2022
When mathematical optimization is applied to a multi-objective design problem, it is the common practice of decision support to generate Pareto optimal solutions as alternatives and clarify their trade-offs. The decision-maker selects any design solution
Masato TOI   +2 more
doaj   +1 more source

The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review

open access: yesNova Biotechnologica et Chimica, 2014
The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto   +3 more
doaj   +1 more source

Combinatorial Method/High Throughput Strategies for Hydrogel Optimization in Tissue Engineering Applications

open access: yesGels, 2016
Combinatorial method/high throughput strategies, which have long been used in the pharmaceutical industry, have recently been applied to hydrogel optimization for tissue engineering applications.
Laura A. Smith Callahan
doaj   +1 more source

Combinatorial RNA Design: Designability and Structure-Approximating Algorithm [PDF]

open access: yes, 2015
In this work, we consider the Combinatorial RNA Design problem, a minimal instance of the RNA design problem which aims at finding a sequence that admits a given target as its unique base pair maximizing structure.
A Avihoo   +20 more
core   +4 more sources

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