Results 51 to 60 of about 16,552 (267)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

APPLICATIONS OF BRANCH-BOUND ALGORITHM TO SOLVE SOME OPTIMAL PROBLEMS RELATED TO THE HAMILTONIAN CYCLE BASED ON THE TSP

Tạp chí Khoa học Đại học Đà Lạt, 2017
The Traveling Salesman Problem (TSP) is the most prominent of the combinatorial optimization problems that belongs to NP-Hard. The best algorithm for solving TSP is the branch-bound algorithm with exponential-time complexity.
Đỗ Như An
doaj   +1 more source

A Combinatorial Optimization Approach for Air Cargo Palletization and Aircraft Loading

Mathematics, 2023
The current air cargo loading plan handles the Air Cargo Palletization Problem (ACPP) and the Aircraft Weight and Balance Problem (WBP) separately, which has an impact on the optimization of the payload and the aircraft’s center of gravity (CG).
Xiangling Zhao, Yun Dong, Lei Zuo
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

On the Problem of a Linear Function Localization on Permutations

Кібернетика та комп'ютерні технології, 2020
Combinatorial optimization problems and methods of their solution have been a subject of numerous studies, since a large number of practical problems are described by combinatorial optimization models.
G.A. Donets, V.I. Biletskyi
doaj   +1 more source

Optimization heuristics for the combinatorial auction problem [PDF]

The 2003 Congress on Evolutionary Computation, 2003. CEC '03., 2004
This work presents and compares three heuristics for the combinatorial auction problem. Besides a simple greedy (SG) mechanism, two metaheuristics, a simulated annealing (SA), and a genetic algorithm (GA) approach are developed which use the combinatorial auction process to find an allocation with maximal revenue for the auctioneer.
Schwind, Michael, Stockheim, Tim, Rothlauf, Franz   +2 more
openaire   +3 more sources