Results 41 to 50 of about 14,077 (306)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Inferring a network from dynamical signals at its nodes.
PLoS Computational Biology, 2020 We give an approximate solution to the difficult inverse problem of inferring the topology of an unknown network from given time-dependent signals at the nodes.
Corey Weistuch +3 more
doaj +1 more source
Tumor Phylogeny Topology Inference via Deep Learning
iScience, 2020 Summary: Principled computational approaches for tumor phylogeny reconstruction via single-cell sequencing typically aim to build the most likely perfect phylogeny tree from the noisy genotype matrix – which represents genotype calls of single cells ...
Erfan Sadeqi Azer +4 more
doaj +1 more source
, 2021 Framed combinatorial topology is a novel theory describing combinatorial phenomena arising at the intersection of stratified topology, singularity theory, and higher algebra. The theory synthesizes elements of classical combinatorial topology with a new combinatorial approach to framings.
Dorn, Christoph, Douglas, Christopher L.
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Superposition induced topology changes in quantum gravity
Journal of High Energy Physics, 2017 We show that superpositions of classical states in quantum gravity with fixed topology can lead to new classical states with a different topology. We study this phenomenon in a particular limit of the LLM geometries.
David Berenstein, Alexandra Miller
doaj +1 more source
Calculating Complete Lists of Belyi Pairs
Mathematics, 2022 Belyi pairs constitute an important element of the program developed by Alexander Grothendieck in 1972–1984. This program related seemingly distant domains of mathematics; in the case of Belyi pairs, such domains are two-dimensional combinatorial ...
Nikolai M. Adrianov, George B. Shabat
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Optimizing the topological and combinatorial complexity of isosurfaces [PDF]
Computer-Aided Design, 2005 Since the publication of the original Marching Cubes algorithm, numerous variations have been proposed for guaranteeing water-tight constructions of triangulated approximations of isosurfaces. Most approaches divide the 3D space into cubes that each occupy the space between eight neighboring samples of a regular lattice.
Andújar Gran, Carlos Antonio +5 more
openaire +3 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source