Results 51 to 60 of about 14,077 (306)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

International Journal of Mathematical Combinatorics, Vol.5 [PDF]

, 2011
The International J.Mathematical Combinatorics (ISSN 1937-1055) is a fully refereed international journal, sponsored by the MADIS of Chinese Academy of Sciences and published in USA quarterly comprising 460 pages approx.
Mao, Linfan (Editor-in-Chief)
core   +1 more source

Energy-Efficient Distributed Topology Control Algorithm for Low-Power IoT Communication Networks

IEEE Access, 2016
Topology control is one of the significant research topics in traditional wireless networks. The primary purpose of topology control ensures the connectivity of wireless nodes participated in the network.
Gangman Yi, Jong Hyuk Park, Sangil Choi
doaj   +1 more source

TOPOLOGY OF COMBINATORIAL DIFFERENTIAL MANIFOLDS

Topology, 1999
Combinatorial differential manifolds (CD manifolds) were introduced by \textit{R. MacPherson} [Combinatorial differential manifolds, in `Topological methods in modern mathematics', Proceedings of a symposium in honor of John Milnor's sixtieth birthday, 203-221 (1993; Zbl 0812.57019)].
openaire   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

On Artin's braid group and polyconvexity in the calculus of variations [PDF]

, 2003
Let Ω ⊂ 2 be a bounded Lipschitz domain and let F : Ω × 2×2 + −→ be a Carathèodory integrand such that F (x, ·) is polyconvex for L2-a.e. x ∈ Ω. Moreover assume that F is bounded from below and satisfies the condition F (x, ξ) ∞ as det ξ 0 for L2-
ALI TAHERI, Taheri, Ali, Ali Taheri (4461328)   +2 more
core   +1 more source

A Structure-Based Coarse-Fine Approach for Diversity Tuning in Cellular GAs

Advances in Electrical and Computer Engineering, 2012
This article empirically assesses a coarse-fine approach for diversity tuning in cellular Genetic Algorithms (cGAs). The coarse tuning is performed through the constant reconfiguration of the grid while the fine tuning is locally achieved through ...
MORALES-REYES, A., ERDOGAN, A. T.
doaj   +1 more source