Results 81 to 90 of about 44,713 (301)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Development of a combined harvester navigation control system based on visual simultaneous localization and mapping-inertial guidance fusion

Journal of Agricultural Engineering
Recently, the existing unmanned systems of combine harvesters mostly adopts satellite navigation scheme, lacking real-time observation of harvesting adjustment.
Jin Chen, Fuhao Zhu, Zhuohuai Guan, Yahui Zhu, Hao Shi, Kai Cheng   +5 more
doaj   +1 more source

Puimurin elevaattorin kapasiteetin mittaus [PDF]

, 2014
Opinnäytetyön aiheena oli tutkia puimurin viljaelevaattoriin sopivaa anturia, joka mittaa kuljetettavan materiaalin määrää. Tavoitteena oli rakentaa kokonaisuus, jonka avulla puimurin kuljettaja saa tiedon viljaelevaattorissa kulkeutuvan viljan määräästä.
Hietanen, Miika
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Lábon álló kalászosok közvetlen cséplésének kutatása = Direct threshing of unmown cereal [PDF]

, 2008
A 2004-2007 közötti pályázati időszakban két területen folytattunk kutatásokat: az eredeti cél szerinti - lábon álló kalászosok közvetlen cséplésével, valamint - nagy munkaszélességű, vékony rétegű csépléssel Közvetlen kalászcséplésnél az ...
Kurtán, Sándor, Láng, Zoltán, Nagy, Sándor   +2 more
core  

Macro- and microscale gaseous diffusion in a Stagnic Luvisol as affected by compaction and reduced tillage [PDF]

, 2008
Intensification of mechanical agriculture has increased the risk for soil compaction and deformation. Simultaneously, reduced tillage practices have become popular due to energy saving and environmental concerns, as they may strengthen and improve the ...
Fazekas-Becker, Orsolya, Horn, Rainer, Simojoki, Asko   +2 more
core   +3 more sources

System analysis of combined harvester work at sunflower harvesting

The Agrarian Scientific Journal, 2018
The article presents an analysis of the technical systems of combined harvester at sunflower harvesting. The mathematical expressions describing technological processes of interaction of systems of the combine with a heap of sunflower, or its processing are resulted. The influence of a reaper, threshing-separating device and cleaning on the loss of oil
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source