Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Impact of working speed of towed picker and combines harvester to the quality of chamomile harvesting [PDF]
The areas under aromatic, herb and medicinal plants in Croatia are constantly increasing, and natural geographical conditions are extremely favorable for organic cultivation of medicinal plants in all parts of the Croatia.
Vesna Očić +4 more
doaj +1 more source
Analisis Ergonomika Penggunaan Mini Rice Combine Harvester
Mini rice combine harvester adalah mesin pemanen padi yang saat ini banyak dioperasikan di lahan sawah. Penelitian ini bertujuan untuk mengetahui ergonomika mesin mini rice combine harvester dalam pemanenan padi di lahan sawah berukuran sempit. Pengujian
Rachmat Suyisto +2 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Analysis of load displacement in grape harvesters and corresponding effect on dynamic weighing system under laboratory conditions [PDF]
Harvester bin dynamic weighing systems are affected by a number of sources of variation such as field slopes and load displacement. In grape harvesters, the nature of the material (wine grapes and wine grape juice) and its relative composition can vary ...
Baerdemaeker, Josse de +6 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Comparing Hemp Seed Yields (Cannabis sativa L.) of an On-Farm Scientific Field Experiment to an On-Farm Agronomic Evaluation Under Organic Growing Conditions in Lower Austria [PDF]
Hemp seed yields of the variety Fedora-19 in an on-farm scientific field experiment on small plots and in an on-farm evaluation in 11 hemp fields under practical organic growing conditions in Lower Austria were compared to give a realistic view of the ...
Lissek-Wolf, G. +2 more
core
European energy crops: A synthesis [PDF]
The European Energy Crops Overview (EECO) project was carried out with 20 partners from fourteen EU countries during 1996. The EECO-project provides the state-of-the-art on energy crops activities in Europe.
Foster, C.A. +2 more
core +2 more sources
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Investigating the influence of fine-dispersed aluminum, nickel and titanium on the properties of phenylone [PDF]
Розглянуто вплив металевих наповнювачів на фізико-механічні та трибологічні характеристики ароматичного поліаміду фенілон – багатообіцяючий термостійкий полімер конструкційного призначення, який може довго експлуатуватися до температури 533 К та не ...
Burya, Aleksandr +5 more
core +1 more source

