Results 51 to 60 of about 2,960,250 (255)

Combining real-time elastography with fine-needle aspiration biopsy to identify malignant thyroid nodules

Journal of International Medical Research, 2020
Objectives To evaluate the diagnostic performance of real-time elastography (RTE) combined with fine-needle aspiration (FNA) biopsy in identifying malignant thyroid nodules.
Lei Zhu, Yanyan Chen, Huijun Ai, Wei Gong, Bin Zhou, Yonghong Xu, Shuzheng Chen, Feng Cheng   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

eipm/ai-biopsy: v1.2.3

, 2021
Biopsy-free prediction of prostate cancer aggressiveness using deep learning and radiology ...
Alexandros Sigaras, Maurice Spiewack, Pantelis Zisimopoulos   +2 more
core   +1 more source

Integration of PSAd and multiparametric MRI to forecast biopsy outcomes in biopsy-naïve patients with PSA 4~20 ng/ml

Frontiers in Oncology
IntroductionThis study aims to investigate whether the transrectal ultrasound-guided combined biopsy (CB) improves the detection rates of prostate cancer (PCa) and clinically significant PCa (csPCa) in biopsy-naïve patients.
Lei Ren, Yanling Chen, Zixiong Liu, Guankai Huang, Weifeng Wang, Weifeng Wang, Xu Yang, Baohua Bai, Yan Guo, Jian Ling, Xiaopeng Mao   +10 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Роль и значение мультипараметрической магнитно-резонансной томографии в диагностике рака предстательной железы [PDF]

, 2017
The problem of timely diagnosis and malignancy grade evaluation of prostate cancer is especially urgent considering continuous and progredient increase in morbidity and mortality caused by this nosology, as well as difficulty of diagnostics.
I. E. Turin, Б. Ш. Камолов, Ю. В. Буйденок, В. Б. Матвеев, B. Sh. Kamolov, G. I. Akhverdieva, И. И. Абдуллин, В. О. Панов, V. B. Matveev, V. A. Chernyaev, V. O. Panov, Yu. V. Buydenok, В. А. Черняев, И. Е. Тюрин, Ph. A. Kossov, I. I. Abdullin, Ф. А. Коссов, Г. И. Ахвердиева   +17 more
core   +4 more sources

A Prospective Comparison of MRI-Guided Targeted Biopsy with 12-Core Transrectal Ultrasound-Guided Systematic Biopsy in the Diagnosis of Clinically Significant Prostate Cancer: An Indian Experience

Indian Journal of Radiology and Imaging
Objective The aim of this study was to compare the sensitivity and prostate cancer detection rate of magnetic resonance (MR) in-bore biopsy with transrectal ultrasound (TRUS) guided systematic biopsy. We also compared the cancer detection
Arjunlokesh Netaji, Vijay Kubihal, Raju Sharma, Amlesh Seth, Seema Kaushal, Chandan J. Das   +5 more
doaj   +1 more source

Tubular atrophy/interstitial fibrosis scores of Oxford classification combinded with proteinuria level at biopsy provides earlier risk prediction in lgA nephropathy

Scientific Reports, 2017
The predictive effect of combining MEST with clinical data at biopsy on renal survival outcomes has not been investigated in patients with IgA nephropathy (IgAN).
Xuejing Zhu, Huiqiong Li, Yexin Liu, Jing You, Zhong Qu, Shuguang Yuan, Youming Peng, Fuyou Liu, Hong Liu   +8 more
doaj   +1 more source