Results 61 to 70 of about 66,645 (249)

Optimization configuration of coal mine multi-energy complementary heat and power coordinated supply system in western China

Meitan xuebao
With the advancement of the “dual-carbon”goal, utilizing renewable energy resources to reduce carbon emissions in the coal mining process has become a significant development trend.However, the construction of mine multi-energy complementary systems ...
Longfei WANG, Shuai WANG, Qing LI, Ruihua LI, Jin WU, Yi XIANG, Zhe BING   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Combined Heat and Power Dispatch Considering Heat Storage of Both Buildings and Pipelines in District Heating System for Wind Power Integration

Energies, 2017
The strong coupling between electric power and heat supply highly restricts the electric power generation range of combined heat and power (CHP) units during heating seasons.
Ping Li, Haixia Wang, Quan Lv, Weidong Li   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Energy and Exergy Evaluations of a Combined Heat and Power System with a High Back-Pressure Turbine under Full Operating Conditions

Energies, 2020
High back-pressure technology is a promising method for the waste heat recovery of exhaust steams in combined heat and power systems. In this research, a 300 MW coal-fired subcritical combined heat and power system was selected as the reference system ...
Shifei Zhao, Weishu Wang, Zhihua Ge
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Analysis of Energy Consumption and Economy of Regional Gas Tri-Supply Composite System

Buildings
With the development of Chinese society, there is an increasing demand for emissions reduction and the stable operation of the power grid. Regional comprehensive energy supply systems have entered the public’s view owing to their advantages of reducing ...
Mingyu Deng, Yuxi Chen, Jun Lu, Hao Shen, Haibo Yang, Shengyu Li, Jie Yuan   +6 more
doaj   +1 more source

Characteristics Analysis of the Heat-to-Power Ratio from the Supply and Demand Sides of Cities in Northern China

Energies, 2020
Combined heat and power (CHP), an efficient heating method with cascades use of energy, accounts for approximately 50% of the heat sources in northern China.
Shunyong Yin, Jianjun Xia, Yi Jiang
doaj   +1 more source