Results 71 to 80 of about 66,645 (249)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Comparative Assessment of Heat Transfer Enhancement Techniques for PCM-Based Latent Heat Thermal Energy Storage [PDF]

EPJ Web of Conferences
Renewable energy systems require efficient storage solutions to mitigate the temporal mismatch between supply and demand. Among various storage concepts, latent heat thermal energy storage (LHTES) systems based on phase change materials (PCM) offer high ...
Anflous Abdelhakim, El Alami Mustapha, Mourid Amina, Errebii Mohamed, Amine Fatima Zahra Laktaoui   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Efficiency Growth of Combined-cycle Cogeneration Plant with the Heat Supply System

Problems of the Regional Energetics, 2015
Energy efficiency of modern technologies of the combined production of heat and electricity and ways of energy saving on base of recycling secondary energy sources has been estimated. It is shown that the most effective for cogeneration are combined-cycle plants.
Denysova Alla, Mazurenko A.S., Denysova Anastasiia   +2 more
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

HOME ENERGY SUPPLY-DEMAND ANALYSIS FOR COMBINED SYSTEM OF SOLAR HEAT COLLECTOR AND HEAT PUMP WATER HEATER

Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research), 2011
混合整数線形計画法を用いた家庭内機器最適運転計画モデルを拡張し，太陽熱集熱器とヒートポンプ給湯機を併用した住宅におけるエネルギー需給解析を行った．現行の電気料金およびヒートポンプ給湯機の運用方法の下での解析結果より，太陽熱集熱器とヒートポンプ給湯機を併用した住宅においても十分な省エネ効果およびCO2排出削減効果が得られることが分かった．また，将来に期待されるヒートポンプ給湯機の電力需給バランス調整機能について，太陽熱の利用による調整力減少の影響を分析した．ヒートポンプ給湯機の昼間の運転量は減少するが，太陽光発電余剰電力の売電量低減効果も得られることが分かった．
Takashi IKEGAMI, Kazuto KATAOKA, Yumiko IWAFUNE, Kazuhiko OGIMOTO   +3 more
openaire   +2 more sources