Results 121 to 130 of about 659,807 (312)

Analysis of edge stress of combined shell under internal waves

AIP Advances
Internal wave is essentially a gravity wave induced by the layered structure of water (e.g., density stable layering), with its maximum amplitude occurring within the ocean.
Yiqiong Cui
doaj   +1 more source

Combined effects of thermal stress and ice impacts on polar ship hulls: A numerical study

Applied Ocean Research
In polar environments, the combined effects of low temperatures and ice loads greatly influence the structural response of ships. While existing studies have primarily focused on individual factors, systematic analysis of their combined effects is ...
Hegang Ji, Jian Zhang, Junjie Liu, Shi Hua, Renwei Liu, A.T. Bekker   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Numerical Simulation and Tests of Lateral Bearing Capacity of Sloped Offshore Monopile Under Vertical Load and Lateral Cyclic Load

Journal of Marine Science and Engineering
Offshore monopile foundations endure complex loads during service. They bear vertical loads from the superstructure’s self-weight and lateral cyclic loads (e.g., wind, waves), while near-coastal seabeds are usually sloped.
Yongqing Lai, Gen Xiong, Ben He, Yilong Sun, Lin Guo, Kaiyuan Liu   +5 more
doaj   +1 more source

Mission load dynamic tests of two undensified Space shuttle thermal protection system tiles [PDF]

Two tests of undensified Space Shuttle thermal protection tiles under combined static and dynamic loads were conducted. The tiles had a density of approximately 144 Kg/cum (LI900 tiles) and were mounted on a strain isolation pad which was 0.41 cm (.160 ...
Gowdey, J. C., Leatherwood, J. D.
core   +1 more source

Water Quality Sampling, Analysis and Annual Load Determinations for Nutrients and Solids on the Ballard Creek, 2008 [PDF]

, 2009
The Arkansas Water Resources Center monitored water quality at Ballard Creek at the Washington County Road 76 Bridge in northwest Arkansas during base flow and storm events from July 1, 2008 through June 30, 2009. Water samples were collected manually or
Cash, L.W., Haggard, B.E., Massey, L.B.
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Analysis on the Dynamic Behavior of Space Shafting under Combined Load

Shock and Vibration
The space shafting is the core component of the momentum exchange attitude control actuator for spacecraft.The dynamic behavior of space shafting has an important impact on the performance of the actuators. Based on the dynamic theory of rolling bearing,
Yan Zhao, Fei Gao, Yulei Xia, Jinfang Gu, Yameng Wang, Sen Zhao   +5 more
doaj   +1 more source