Results 131 to 140 of about 666,236 (309)

Metal-truss wing spars [PDF]

open access: yes
The purpose of the study was to develop improvements in the current methods for the calculation of the loads in members of metal truss wing spars which are subjected to combined bending and compression.
Swickard, Andrew E
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Numerical Simulation and Tests of Lateral Bearing Capacity of Sloped Offshore Monopile Under Vertical Load and Lateral Cyclic Load

open access: yesJournal of Marine Science and Engineering
Offshore monopile foundations endure complex loads during service. They bear vertical loads from the superstructure’s self-weight and lateral cyclic loads (e.g., wind, waves), while near-coastal seabeds are usually sloped.
Yongqing Lai   +5 more
doaj   +1 more source

Use of Flexible Body Coupled Loads in Assessment of Day of Launch Flight Loads [PDF]

open access: yes, 2011
A Day of Launch flight loads assessment technique that determines running loads calculated from flexible body coupled loads was developed for the Ares I-X Flight Test Vehicle.
Olds, Aaron D.   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Analysis on the Dynamic Behavior of Space Shafting under Combined Load

open access: yesShock and Vibration
The space shafting is the core component of the momentum exchange attitude control actuator for spacecraft.The dynamic behavior of space shafting has an important impact on the performance of the actuators. Based on the dynamic theory of rolling bearing,
Yan Zhao   +5 more
doaj   +1 more source

Water Quality Sampling, Analysis and Annual Load Determinations for Nutrients and Solids on the Ballard Creek, 2008 [PDF]

open access: yes, 2009
The Arkansas Water Resources Center monitored water quality at Ballard Creek at the Washington County Road 76 Bridge in northwest Arkansas during base flow and storm events from July 1, 2008 through June 30, 2009. Water samples were collected manually or
Cash, L.W., Haggard, B.E., Massey, L.B.
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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