Results 131 to 140 of about 659,807 (312)

Chaotic dynamics of fractional viscoelastic PET membranes subjected to combined harmonic and variable axial loads

Results in Physics
Nonlinear chaotic vibrations of fractional viscoelastic PET (polyethylene terephthalate) membranes subjected to combined harmonic and variable axial loads is investigated in this paper.
Jiajuan Qing, Shisheng Zhou, Jimei Wu, Mingyue Shao   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A Multi-Parameter Perturbation Solution for Functionally Graded Piezoelectric Cantilever Beams under Combined Loads. [PDF]

Materials (Basel), 2018
Lian Y, He X, Shi S, Li X, Yang Z, Sun J.   +5 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Evaluation of the impact of soil–cement retrofitting on the failure behaviour of wharf piles in liquefiable soils

Applied Ocean Research
Liquefaction-induced lateral spreading significantly contributes to pile bending failure in pile-supported wharves. However, the combined effects of axial and lateral loads under such conditions have been insufficiently investigated, and the efficacy of ...
Zheng Zhang, Shengyi Cong, Liang Tang, Xianzhang Ling, Yun Shi   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Flight tests of Viking parachute system in three Mach number regimes. 2: Parachute test results [PDF]

Tests of the Viking 16.15-meter nominal-diameter disk-gap-band parachute were conducted at Mach number and dynamic pressure conditions which bracketed the range postulated for the Viking '75 mission to Mars.
Bendura, R. J., Lecroy, S. R., Lundstrom, R. R., Renfroe, P. G.   +3 more
core   +1 more source

Tidal turbine blade load experiments for oscillatory motion [PDF]

, 2011
This paper presents blade root bending moment measurements of a horizontal-axis tidal turbine for planar oscillatory motion, conducted in a stationary water towing tank.
Bickerton, S, Day, Alexander, Flay, R.G.J., Milne, I.A., Sharma, R.N.   +4 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source