Results 61 to 70 of about 659,807 (312)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Combined Pitch and Trailing Edge Flap Control for Load Mitigation of Wind Turbines
Energies, 2018 Using active control methods for load mitigation in wind turbines could greatly reduce the cost of per kilowatt hour of wind power. In this work, the combined pitch and trailing edge flap control (CPFC) for load mitigation of wind turbines is ...
Keshan He +3 more
doaj +1 more source
Deformation coordination analysis of CC-RCC combined dam structures under dynamic loads
Water Science and Engineering, 2020 A combined dam structure using different concrete materials offers many practical benefits. There are several real-world cases where large-volume heterogeneous concrete materials have been used together.
Bo-wen Shi +4 more
doaj +1 more source
Assessing Integrated Water Management Options for Urban Developments - Canberra case study [PDF]
, 2008 Urban water services in the Australian Capital Territory (ACT) are currently provided through conventional centralised systems, involving large scale water distribution, wastewater collection, water and wastewater treatment.
Diaper, Clare +4 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Journal of Hydrology: Regional Studies, 2015 Study region: Bavaria, Germany. Study focus: The Altmühl River is prone to nutrient inputs from agricultural activities. Quantifying nitrate nitrogen (NO3−-N) and total phosphorus (TP) concentrations due to potential future changes in the watershed is ...
B. Mehdi, R. Ludwig, B. Lehner
doaj +1 more source
A procedure for combining acoustically induced and mechanically induced loads (first passage failure design criterion) [PDF]
The combined load statistics are developed by taking the acoustically induced load to be a random population, assumed to be stationary. Each element of this ensemble of acoustically induced loads is assumed to have the same power spectral density (PSD ...
Crowe, D. R., Henricks, W.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source