Recent advances in combined modality therapy. [PDF]
Abstract Combined modality therapy emerged from preclinical data showing that carefully chosen drugs could enhance the sensitivity of tumor cells to radiation while having nonoverlapping toxicities. Recent advances in molecular biology involving the identification of cellular receptors, enzymes, and pathways involved in tumor growth and ...
Mierzwa ML+3 more
europepmc +10 more sources
Radiation-induced prodrug activation: extending combined modality therapy for some solid tumours. [PDF]
Combined chemoradiotherapy is the standard of care for locally advanced solid tumours. However, systemic toxicity may limit the delivery of planned chemotherapy. New approaches such as radiation-induced prodrug activation might diminish systemic toxicity,
Farrer NJ, Higgins GS, Kunkler IH.
europepmc +3 more sources
Combined Modality Therapy of Gemcitabine and Radiation [PDF]
Abstract Learning Objectives After completing this course, the reader will be able to: List the advantages of combination chemotherapy and radiotherapy. Explain the rationale for doing in vitro research in the radiochemotherapy field.
Bea Pauwels+3 more
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Barriers to Combined-Modality Therapy for Limited-Stage Small Cell Lung Cancer.
Importance Combined-modality therapy with chemotherapy and radiation therapy plays a crucial role in the upfront treatment of patients with limited-stage small cell lung cancer (SCLC), but there may be barriers to utilization in the United States ...
Pezzi TA+9 more
europepmc +2 more sources
Treatment of Obstructive Sleep Apnea. Prospects for Personalized Combined Modality Therapy. [PDF]
Obstructive sleep apnea (OSA) is a common sleep disorder with serious associated morbidities. Although several treatment options are currently available, variable efficacy and adherence result in many patients either not being treated or receiving ...
Deacon NL, Jen R, Li Y, Malhotra A.
europepmc +2 more sources
Targeted radionuclide therapy in combined-modality regimens [PDF]
Targeted radionuclide therapy (TRT) is a branch of cancer medicine concerned with the use of radioisotopes, radiolabelled molecules, nanoparticles, or microparticles that either naturally accumulate in or are designed to target tumours. TRT combines the specificity of molecular and sometimes physical targeting with the potent cytotoxicity of ionising ...
Gill, MR, Falzone, N, Du, Y, Vallis, KA
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Prostatic Leiomyosarcoma: The Case for Combined Modality Therapy [PDF]
Patient. A 65‐year old man who had previously undergone surgery for benign prostatic hyperplasia presented with symptoms of recurrent bladder outflow obstruction. Cystoscopy revealed the presence of recurrent tissue.Results. Histology identified a leiomyosarcoma.
Keith Vaughton, Salah El-Sharkawi
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Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy [PDF]
There is no consensus on the management of locally advanced pancreatic cancer, with either chemotherapy or combined modality approaches being employed (Maheshwari and Moser, 2005).
A Jemal+39 more
core +3 more sources
Editorial: Developing combined modality therapy with mitochondria-targeting strategy [PDF]
Yong Teng, Yong Teng
doaj +2 more sources
Medulloblastoma: Results with combined modality therapy
The results of treatment of posterior fossa (PF) medulloblastomas treated at UCSF between 1966 and 1987 were analyzed. 65 patients (pts) were treated postoperatively with craniospinal radiation therapy (CS XRT). The PF dose was 54 Gy. Initially spinal doses of 30-40 Gy, cranial doses of 40-50 Gy were given. Late sequelae were noted.
F. Halberg+7 more
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