Results 241 to 250 of about 167,795 (308)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients. [PDF]

Ther Adv Med Oncol
Arendt N, Payo-Serafín T, Kolosenko A, Kopsida M, Sjöblom M, Heindryckx F.   +5 more
europepmc   +1 more source

Comparative effectiveness of different core muscle training regimens for chronic non-specific low back pain: a systematic review and meta-analysis. [PDF]

Front Med (Lausanne)
Liu Y, Yu Y, Lu F, Liu J.
europepmc   +1 more source

Meta-analysis of the therapeutic effects of different core muscle training on pain and function in patients with chronic non-specific low back pain. [PDF]

Front Pain Res (Lausanne)
Liu Y, Li H, Yu Y, Zhang C, Zhou Z.
europepmc   +1 more source

Combined Modality Therapy for Thoracic and head and Neck Cancers: A Review of Updated Literature Based on a Consensus Meeting

Tumori, 2016
Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated,
Pierfrancesco Franco, Alba Fiorentino, Francesco Dionisi   +2 more
exaly   +2 more sources

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Combined modality therapy

Current Opinion in Oncology, 1991
Encouraging results continue to emerge with the use of chemoradiotherapy. This review of the current literature demonstrates some of the advances that have been achieved in a variety of common malignancies with strategies based on well-defined rationales.
C J, McGinn, T J, Kinsella
openaire   +2 more sources

Combined modality therapy of esthesioneuroblastoma

Otolaryngology–Head and Neck Surgery, 2007
ObjectiveEsthesioneuroblastoma (ENB) is a rare tumor of the olfactory epithelium. The objective of this study was to evaluate treatment modalities including surgery, IMRT, and chemotherapy and patient outcomes.Patients and MethodsA retrospective analysis was performed on a total of 21 patients.
J Nicolas, McLean, Sunjay R, Nunley, Carmen, Klass, Charles, Moore, Susan, Müller, Peter A S, Johnstone   +5 more
openaire   +2 more sources

Combined‐modality therapy for gastric cancer

Seminars in Surgical Oncology, 2003
AbstractGastric cancer has a poor prognosis. It is often diagnosed at an advanced stage, and potentially curative treatments often can not be exercised. Even when a curative surgical resection is possible, only a minority of patients survive beyond 5 years, and locoregional failures are frequent among patients undergoing curative resections.
James C, Yao, Paul F, Mansfield, Peter W T, Pisters, Barry W, Feig, Nora A, Janjan, Christopher, Crane, Jaffer A, Ajani   +6 more
openaire   +2 more sources