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Combined modality therapy for pancreatic cancer
Seminars in Oncology, 2003In spite of the high mortality in pancreatic cancer, significant progress is being made. This review discusses multimodality therapy for patients with pancreatic cancer. According to several phase II trials and Gastrointestinal Tumor Study Group results, improvements in locoregional control and survival may be achieved when chemotherapy is added to ...
James Y, Tsai +2 more
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Combined modality therapy for gynecologic cancer
Current Opinion in Oncology, 1995The use of combined modality therapy in the primary management of gynecologic cancer continues to be explored. Although early ovarian cancer is treated with postoperative adjuvant treatment, the data to support its value is lacking. In advanced disease, paclitaxel has emerged as the most optimal treatment after maximal cytoreduction.
I, Ackerman, G M, Thomas
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Combined modality therapy for esophageal cancer
Current Oncology Reports, 1999Whereas many patients with esophageal carcinoma present with what appears to be localized disease, cure rates with surgical resection alone remain low. Although surgical resection, where feasible, affords patients the best chance of cure, the primary tumor has often invaded local tissues or structures, and occult micrometastases often exist at the time
Z, Gamliel, M J, Krasna
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Combined modality therapy of esophageal carcinoma
Cancer, 1981One hundred ten patients with epidermoid carcinoma of the esophagus were treated at the Memorial Sloan-Kettering Cancer Center (MSKCC) with combined modality techniques involving preoperative irradiation (RT) and surgery, and with preoperative chemotherapy (CT), surgery, and irradiation.
D P, Kelsen +7 more
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Combined Modality Therapy of Gastric Cancer
Surgical Oncology Clinics of North America, 1997Most patients with adenocarcinoma of the stomach continue to present with advanced stages of disease. Although cure is not possible without complete resection, most patients will go on to recur and die of their disease. Despite the efforts of the last 3 to 4 decades, little progress has been made in improving disease specific survival.
M S, Karpeh, D P, Kelsen
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2014
Radiation therapy can be modified by increasing the effectiveness of radiation on tumors (radiosensitizers), protecting normal tissues (radioprotectors), increasing oxygen concentration, or by using systemic therapy drugs. Radio-protectors are described by their dose reduction factor (DRF) while radio-sensitizers are described by their enhancement ...
David S. Chang +4 more
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Radiation therapy can be modified by increasing the effectiveness of radiation on tumors (radiosensitizers), protecting normal tissues (radioprotectors), increasing oxygen concentration, or by using systemic therapy drugs. Radio-protectors are described by their dose reduction factor (DRF) while radio-sensitizers are described by their enhancement ...
David S. Chang +4 more
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Combined Modality Therapy for Rectal Cancer
The Cancer Journal, 2016The primary therapy for any potentially curative rectal cancer is surgery. For locally advanced tumors (i.e., T3-4 and/or node positive), the very high rate of local and distant recurrences has necessitated a standard adjuvant regimen of preoperative chemoradiation and postoperative chemotherapy.
Sagar A, Patel +2 more
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Combined Modality Therapy in the Elderly Population
Current Treatment Options in Oncology, 2009The incidence of cancer among older patients continues to rise. The use of combined modality therapy has improved survival in a variety of malignancies, including rectal, head and neck, and lung cancer; however, the addition of chemotherapy increases substantially the toxicities of treatment.
Lilie L, Lin, Stephen M, Hahn
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Combined Modality Therapy for Rectal Cancer
The Cancer Journal, 2010The standard adjuvant treatment for cT3 and/or N+ rectal cancer is preoperative chemoradiation. However, there are many controversies regarding this approach. These include the role of short course radiation, whether postoperative adjuvant chemotherapy necessary for all patients and whether the type of surgery after chemoradiation should be based on ...
Minsky, Bd +2 more
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Combined Modality Therapy of Esophageal Cancer
Journal of the National Comprehensive Cancer Network, 2008Esophageal cancer is a deadly disease. Only one third of patients with localized disease experience long-term survival. Over the past 20 years, investigators have evaluated neoadjuvant strategies to improve the outcomes of surgical management. Chemotherapy and radiation have been evaluated individually and in combination for preoperative management of ...
Rosalyn A, Juergens, Arlene, Forastiere
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