Results 51 to 60 of about 9,967,589 (303)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Combined modality treatment of American Burkittapos;s lymphoma [PDF]
Cancer, 1976 Fifteen American patients with Burkitt's lymphoma were treated in a clinical trial employing chemotherapy, radiotherapy, and immunotherapy. Two patients died during induction, and 13 achieved complete responses. Eight patients relapsed at a median of 11 weeks from initial treatment, and seven of these have died.
J L, Ziegler +6 more
openaire +2 more sources
Conceivability, Apriority and Modality [PDF]
, 2011 I aim to understand whether apriority entails necessity, aposteriority entails contingency and conceivability entails possibility; that is, the relationship between, and the nature of, rationality and modality.
WINSTANLEY, PAUL
core
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Results of combined modality treatment for nasopharyngeal cancer
Journal of Cancer Research and Therapeutics, 2009 Radiotherapy is the cornerstone of treatment in nasopharyngeal cancer (NPC); the addition of chemotherapy has shown improved results.To compare the results of concurrent chemoradiation with that of radiotherapy alone in NPC.One hundred and ninety consecutive NPC patients, without distant metastasis, who reported to the institute from January 1992 to ...
Venkitaraman, Ramachandran +3 more
openaire +2 more sources
, 1991 In the initial series of 198 patients treated at the National Cancer Institute (NCI) with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy for Hodgkin's disease, a review of presenting chest radiographs available on 192 of ...
V T DeVita +8 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
TEN-YEAR OUTCOMES AFTER BREAST-CONSERVING SURGERY WITH INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER
Сибирский онкологический журнал, 2017 The purpose of the study was to analyze the 10-year outcomes after breast-conserving surgery with electronbeam intraoperative radiation therapy (IORT) followed by external beam radiotherapy (EBRT) in patients with breast cancer. Material and methods. The
A. V. Doroshenko +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 1992 Thirty-seven patients with stage I-II Hodgkin's disease and massive mediastinal involvement, observed between June 1981 and November 1989, underwent combined modality treatment.
FIACCHINI M. +11 more
core +1 more source