Results 201 to 210 of about 3,553,850 (264)
Clinical Endocrinology, EarlyView.ABSTRACT Objective To evaluate methods used to assess individual iodine status in infants under 2 years of age and to examine their clinical utility in relation to thyroid dysfunction across different clinical contexts. Design The protocol was registered on PROSPERO and followed PRISMA guidelines.
Sabrina Bilston‐John +3 more
wiley +1 more source
Cortisol Cutoffs for Adrenal Insufficiency Using Elecsys II: A Systematic Review
Clinical Endocrinology, EarlyView.ABSTRACT Objective Adrenal insufficiency (AI) is associated with increased risk of morbidity and mortality if improperly managed. Adrenocorticotrophin (ACTH) stimulation testing is the most widely used AI diagnostic test. Historically, a serum cortisol threshold of 500 nmol/L (18.1 µg/dL), derived using polyclonal assays, was widely used.
Sarah Haunton +7 more
wiley +1 more source
Diabetic Medicine, EarlyView.Abstract Aims HNF1B variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD‐HNF1B), but the phenotypic spectrum of variants of uncertain significance (VUS) remains incompletely defined. We aimed to characterise the multisystem phenotype associated with the HNF1B p.E105K variant and to examine the mechanism underlying insulin ...
YunZe Wang +5 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann +3 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background and Aims Chronic stress contributes to cardiometabolic risk, and stress‐reduction interventions have been proposed to improve stress‐sensitive physiology and cardiometabolic health, though evidence remains inconsistent. This study examined the effects of a Transcendental Meditation (TM) intervention on cardiometabolic health and ...
Mahesh Kumar Khanal +5 more
wiley +1 more source
Ethology, EarlyView.To examine how their behaviour and hormones change over different life phases, male guinea pigs experienced two different social environments from juvenility to adulthood. Only one environment contained social stimulation by unfamiliar conspecifics. Although no differences in testosterone and cortisol concentrations were found, it was interesting that ...
Maximilian Baldy, Sylvia Kaiser
wiley +1 more source
The FEBS Journal, EarlyView.FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari +7 more
wiley +1 more source
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source