Generation of Functional GnRH-Responsive Pituitary-like Organoids from Ovine Embryonic Stem Cells [PDF]
CellsThe pituitary gland is a master regulator of endocrine and reproductive physiology; however, the lack of physiologically relevant in vitro models in livestock species has limited studies of pituitary development and endocrine function. Although pituitary
Hua Yang +9 more
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation [PDF]
BiomoleculesThe RNA-binding proteins Musashi1 and Musashi2 (MSI1 and MSI2) regulate stem cell function and tissue plasticity by modulating mRNA translation. While typically known as translational repressors, the MSI1 and MSI2 proteins can also act as context ...
Katherine Bronson +9 more
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Clinics, 2013 OBJECTIVE: The expression of transcription factors involved in early pituitary development, such as PROP1 and POU1F1, has been detected in pituitary adenoma tissues.
Maria Candida Barisson Villares Fragoso +2 more
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Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors [PDF]
Frontiers in EndocrinologyIntroductionCongenital hypopituitarism (CH) is characterized by the deficiency of pituitary hormones. Among CH patients, 85% lack a molecular diagnosis.
Bianca Helena Ventura Fernandes +6 more
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B [PDF]
Scientific ReportsThe Musashi family of sequence-specific RNA binding proteins (Musashi1 and Musashi2) serve a critical role in mediating both physiological and pathological stem cell function in many tissue types by repressing the translation of target mRNAs that encode ...
Katherine Bronson +7 more
doaj +2 more sources
Etiology of combined pituitary hormone deficiency: GNAO1 as a novel candidate gene [PDF]
Endocrine ConnectionsBecause the causes of combined pituitary hormone deficiency (CPHD) are complex, the etiology of congenital CPHD remains unknown in most cases. The aim of the study was to identify the genetic etiology of CPHD in a well-defined single-center cohort.
Lukas Plachy +11 more
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs [PDF]
Scientific ReportsThe pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including reproduction, growth, metabolism and stress responses.
Jewel Banik +12 more
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Contribution of PROP1 in the pathogenesis of Cushing’s disease: A preliminary study
Interdisciplinary Neurosurgery, 2023 Prophet of Pit1 (PROP1) is the pituitary specific transcription factor which was cloned as an upstream regulator of PIT1. Cushing’s disease is caused by corticotroph adenomas which does not belong to the PIT1 lineage.
Noriyoshi Takebe +6 more
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Aged PROP1 deficient dwarf mice maintain ACTH production. [PDF]
PLoS ONE, 2011 Humans with PROP1 mutations have multiple pituitary hormone deficiencies (MPHD) that typically advance from growth insufficiency diagnosed in infancy to include more severe growth hormone (GH) deficiency and progressive reduction in other anterior ...
Igor O Nasonkin +7 more
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Medicina, 2023 Background and Objectives: Combined pituitary hormone deficiency (CPHD) is a rare heterogeneous disease. It is characterized by the deficiency of growth hormone (GH) and shortage of at least one or more other hormones of the pituitary gland including ...
Ahmed M. Almatrafi +2 more
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