Results 41 to 50 of about 2,015 (159)

Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: Frequencies, phenotypes and growth outcomesResearch in context

EBioMedicine, 2018
Background: Pituitary development and GH secretion are orchestrated by multiple genes including GH1, GHRHR, GLI2, HESX1, LHX3, LHX4, PROP1, POU1F1, and SOX3.
Werner F. Blum, Jürgen Klammt, Serge Amselem, Heike M. Pfäffle, Marie Legendre, Marie-Laure Sobrier, Marie-Pierre Luton, Christopher J. Child, Christine Jones, Alan G. Zimmermann, Charmian A. Quigley, Gordon B. Cutler, Jr, Cheri L. Deal, Jan Lebl, Ron G. Rosenfeld, John S. Parks, Roland W. Pfäffle   +16 more
doaj   +1 more source

Management of Azoospermia: A Systematic Approach

The Obstetrician &Gynaecologist, Volume 28, Issue 3, Page 155-167, July 2026.
ABSTRACT Key Content Work‐up of azoospermic men includes a detailed history, physical examination and investigations to find the underlying cause. Causes and management of azoospermia (pre‐testicular, testicular and post‐testicular) with case presentations.
Naimah Raza, Alex Grammatis, Philippa Sangster, Jackson Kirkman‐Brown   +3 more
wiley   +1 more source

Development of the neurohypophysis: A major neuroendocrine interface

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh, Naveen Nedunchezhian, Md Hasan Ali, Sebastian Pęcherz, Natalia Kowalewska, Savani Anbalagan   +5 more
wiley   +1 more source

Association between PROP1 gene polymorphism (g.748G>A) and growth traits in Assam hill goats

Indian Journal of Animal Sciences
PROP1 (Prophet of Pit-1) gene is a key transcription factor involved in pituitary development and regulation of growth-related hormones in livestock.
RAKESH KUMAR, DIPAK BHUYAN, MAHAK SINGH, MEENA DAS, RAHUL KATIYAR, P C CHANDRAN, R K KAMAL, SHANKAR DAYAL, RAJNI KUMARI, AMITAVA DEY, P K RAY, JYOTI KUMAR, S K AHIRWAL, KAMAL SARMA, ANUP DAS   +14 more
doaj   +1 more source

Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes

Archives of Endocrinology and Metabolism, 2023
Objective: Congenital hypopituitarism (CH) is a rare disease characterized by one or more hormone deficiencies of the pituitary gland. To date, many genes have been associated with CH.
Tarık Kırkgöz, Semra Gürsoy, Sezer Acar, Özlem Nalbantoğlu, Beyhan Özkaya, Hüseyin Anıl Korkmaz, Filiz Hazan, Behzat Özkan   +7 more
doaj   +1 more source

Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins. [PDF]

Hormones (Athens)
The most commonly identified genetic cause of combined pituitary hormone deficiency (CPHD) is PROP1 gene mutations. The aim of the study was to compare selected clinical features of patients with CPHD caused by variants of the PROP1 gene (CPHD-PROP1) and
Zygmunt-Górska A, Wójcik M, Gilis-Januszewska A, Starmach A, Bik-Multanowski M, Starzyk JB.   +5 more
europepmc   +2 more sources

Adrenal glands of Prop1 deficient mice are not hypotrophic.

, 2013
Adrenal glands were dissected from 5 and 8 week old female N4 B6 Prop1+/+ and Prop1-/- mice, fixed, embedded, sectioned, and stained with hemotoxylin and eosin (Panels A, C, E, G) and immunostained for 20α-hydroxysteroid dehydrogenase [59] and developed ...
Sally A. Camper (41538), David L. Bavers (338359), Robert D. Ward (182215), Catherine E. Keegan (338362), Igor O. Nasonkin (338358), Gary D. Hammer (338364), Felix Beuschlein (158361), Amanda H. Mortensen (338360)   +7 more
core   +1 more source

The PROP1 2-Base Pair Deletion Is a Common Cause of Combined Pituitary Hormone Deficiency

, 1998
Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in 8000 births. Although the proportion of familial CPHD cases is unknown, about 10% have an affected first degree relative. We have recently reported three mutations in the
Cogan, JD, Fofanova, OV, Mendonca, BB, Agapito, A, Arnhold, IJ, Moreno, A, Bircan, I, Osorio, MG, Phillips, JA, Wu, W   +9 more
core   +2 more sources

Presentation and diagnosis of childhood-onset combined pituitary hormone deficiency: A single center experience from over 30 years

EClinicalMedicine, 2022
Summary: Background: Childhood-onset combined pituitary hormone deficiency (CPHD) has a wide spectrum of etiologies and genetic causes for congenital disease. We aimed to describe the clinical spectrum and genetic etiologies of CPHD in a single tertiary
Johanna Hietamäki, Juho Kärkinen, Anna-Pauliina Iivonen, Kirsi Vaaralahti, Annika Tarkkanen, Henrikki Almusa, Hanna Huopio, Matti Hero, Päivi J. Miettinen, Taneli Raivio   +9 more
doaj   +1 more source

From Empirical Models to Physics‐Informed Neural Networks: The Evolution of Oil Production Forecasting

Journal of GeoEnergy, Volume 2026, Issue 1, 2026.
Production forecasting for oil and gas wells is a decisive element of field‐development planning because it directly guides recovery strategy design, production optimisation and risk management. Conventional methods, including empirical decline‐curve analysis (DCA) and full‐physics numerical simulation, are limited either by their inability to capture ...
Shitan Yin, Erlong Yang, Xianjun Wang, Chi Dong, Mehdi Ostadhassan   +4 more
wiley   +1 more source