Results 51 to 60 of about 2,015 (159)

Genomic Analysis of Hair Sheep From West/Central Africa Reveals Unique Genetic Diversity and Ancestral Links to Breed Formation in the Caribbean

Molecular Ecology, Volume 34, Issue 24, December 2025.
ABSTRACT Cameroon Blackbelly sheep are a domestic breed of hair sheep from West/Central Africa. They are popular with small‐holder farmers in Cameroon as they are highly resilient to local environmental challenges and are prolific a‐seasonal breeders.
Pamela Wiener, Juliane Friedrich, Melissa M. Marr, Gustave Simo, Vincent N. Tanya, Keith T. Ballingall, Pavel Flegontov, Benjamin D. Rosen, Guillaume Sallé, Gordon Spangler, Curtis P. Van Tassell, Mazdak Salavati, Félix Meutchieye, Emily L. Clark   +13 more
wiley   +1 more source

ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System

G3: Genes, Genomes, Genetics, 2020
Proper nervous system development is required for an organism’s survival and function. Defects in neurogenesis have been linked to neurodevelopmental disorders such as schizophrenia and autism.
Elyse L. Christensen, Alexandra Beasley, Jessica Radchuk, Zachery E. Mielko, Elicia Preston, Sidney Stuckett, John I. Murray, Martin L. Hudson   +7 more
doaj   +1 more source

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor. [PDF]

PLoS ONE, 2018
The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function.
John Rooney, Keiyu Oshida, Naresh Vasani, Beena Vallanat, Natalia Ryan, Brian N Chorley, Xuting Wang, Douglas A Bell, Kai C Wu, Lauren M Aleksunes, Curtis D Klaassen, Thomas W Kensler, J Christopher Corton   +12 more
doaj   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, Volume 13, Issue 5, Page 1025-1043, July 2025.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Congenital hypopituitarism: how to select the patients for genetic analyses

Italian Journal of Pediatrics, 2018
Aim of this commentary is to analyze the relationships between genotypic bases and phenotypic expression of congenital “multiple pituitary hormone deficiency” (MPHD) syndrome and to indicate some reliable criteria for selecting the patients who should ...
Giuseppe Crisafulli, Tommaso Aversa, Giuseppina Zirilli, Filippo De Luca, Romina Gallizzi, Malgorzata Wasniewska   +5 more
doaj   +1 more source

Whole-genome sequence analysis reveals selection signatures for important economic traits in Xiang pigs

Scientific Reports, 2022
Xiang pig (XP) is one of the best-known indigenous pig breeds in China, which is characterized by its small body size, strong disease resistance, high adaptability, favorite meat quality, small litter sizes, and early sexual maturity.
Xiying Wang, Xueqin Ran, Xi Niu, Shihui Huang, Sheng Li, Jiafu Wang   +5 more
doaj   +1 more source

Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome

Frontiers in Pediatrics, 2021
Introduction: Congenital hypopituitarism (CH) is characterized by a deficiency of one or more pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and reproduction.
Laura Bosch i Ara, Harshini Katugampola, Mehul T. Dattani, Mehul T. Dattani   +3 more
doaj   +1 more source

New insights in cellular senescence: The pituitary model

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Senescence is a pivotal process in pituitary tumorigenesis. Recent advances have elucidated the complex mechanisms by which key factors, including IL‐6, establish and maintain senescence in these tumors. Given the critical role of senescence and the development of novel techniques to detect senescent cells, the identification of biomarkers and the ...
Florencia Herbstein, Josefina Rosmino, Mirtha Adriana Guitelman, Joaquina Cagliero, David Gonilski‐Pacin, Nicolas Ciancio Del Giudice, Manuel Fiz, Mariana Fuertes, Eduardo Arzt   +8 more
wiley   +1 more source

Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD)

, 2009
Mutations in PROP1 are a frequent cause of familial CPHD. We have described four novel mutations in PROP1 in 3 pedigrees, all resulting in PROP1 deficiency by different mechanisms.
Dattani, M.T., Otonkoski, T., Rhodes, S.J., Al-Khawari, M., Woods-Townsend, Kathryn, Kelberman, D., Turton, J.P.G., Greening, J., Mehta, A., Swift, P.G F.   +9 more
core   +1 more source

Isolation of adult pituitary stem/progenitor cell clusters located in the parenchyma of the rat anterior lobe

Stem Cell Research, 2016
Recent studies have demonstrated that Sox2-expressing stem/progenitor cells play roles in the pituitary cell turnover. Two types of niches have been proposed for stem/progenitor cells, the marginal cell layer (MCL) and the dense cell clusters in the ...
Saishu Yoshida, Naoto Nishimura, Hiroki Ueharu, Naoko Kanno, Masashi Higuchi, Kotaro Horiguchi, Takako Kato, Yukio Kato   +7 more
doaj   +1 more source