Results 71 to 80 of about 2,015 (159)

The circadian rhythm: A key variable in aging?

Aging Cell, Volume 23, Issue 11, November 2024.
In this study, general age‐related transcriptional trajectories in seven organs were investigated over the lifespan of mice. Since both sexes and two strains were used equally, biases in this regard are diminished. Twenty replicas per time provide a deeper insight than usual.
Patrick R. Winterhalter, Adrian‐Iustin Georgevici, Nitin J. Gharpure, Gábor Szabó, Andreas Simm   +4 more
wiley   +1 more source

Paediatric thyroid disease

Clinical Endocrinology, Volume 101, Issue 3, Page 223-233, September 2024.
Abstract The spectrum of thyroid disorders presenting to paediatricians is different to that seen by adult physicians. Referrals reflect cases detected by the neonatal screening programme for congenital hypothyroidism and many of the inherited defects of thyroid hormone generation or action will be manifest in early life. Autoimmune thyroid disease can
Timothy Cheetham, Claire Wood
wiley   +1 more source

Pituitary stalk interruption syndrome is characterized by genetic heterogeneity.

PLoS ONE, 2020
Pituitary stalk interruption syndrome is a rare disorder characterized by an absent or ectopic posterior pituitary, interrupted pituitary stalk and anterior pituitary hypoplasia, as well as in some cases, a range of heterogeneous somatic anomalies.
Raja Brauner, Joelle Bignon-Topalovic, Anu Bashamboo, Ken McElreavey   +3 more
doaj   +1 more source

An epigenetic candidate–gene association study of parental styles in suicide attempters with substance use disorders

Addiction Biology, Volume 29, Issue 4, April 2024.
Investigating methylation levels in stress related pathways, we found significant interactions in paternal dysfunction and a risk of suicidal attempt in patient with multiple addictions under stabilized methadone treatment. Abstract Suicide attempts (SA) are prevalent in substance use disorders (SUD).
Clara Chrétienneau, Leticia M. Spindola, Florence Vorspan, Trine Vik Lagerberg, Cynthia Marie‐Claire, Frank Bellivier, Stéphane Mouly, Jean‐Louis Laplanche, Vanessa Bloch, Stéphanie Le Hellard, Romain Icick   +10 more
wiley   +1 more source

Five novel single nucleotide polymorphisms (SNPs) of the prophet of PIT1 (<i>PROP1</i>) gene in bovine (Brief report)

, 2007
. The prophet of Pit1 (PROP1) gene encodes a paired class homeodomain transcription factor of 226 amino acids and is organized of 3 exons. PROP1 is necessary for the specification, differentiation and proliferation of cells. Its function is essential for
Y. Guo, C. Pan, B. Zhang, C. Lei, H. Chen, X. Lan, L. Hua   +6 more
core   +1 more source

Clinical Features and Analysis in Pituitary Stalk Interruption Syndrome

International Journal of Endocrinology, Volume 2024, Issue 1, 2024.
Objective. Pituitary stalk interruption syndrome (PSIS) is characterized by the absence of pituitary stalk, pituitary hypoplasia, and ectopic posterior pituitary. Because the etiology and clinical cognition of PSIS remain elusive, we analyzed the clinical features of PSIS in Chinese patients. Methods.
Qiuxuan Guo, Jing Zhao, Shuang Yu, Henrik Falhammar   +3 more
wiley   +1 more source

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

Genome Biology, 2017
Background Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging.
John J. Cole, Neil A. Robertson, Mohammed Iqbal Rather, John P. Thomson, Tony McBryan, Duncan Sproul, Tina Wang, Claire Brock, William Clark, Trey Ideker, Richard R. Meehan, Richard A. Miller, Holly M. Brown-Borg, Peter D. Adams   +13 more
doaj   +1 more source

Mutations and Pituitary Morphology in a Series of 82 Patients with <i>PROP1</i> Gene Defects

, 2011
<i>Background/Aims:</i> Defects of the <i>PROP1 </i>gene are the most prevalent genetic cause of combined pituitary hormone deficiency.
Roland Pfaeffle, Barbora Obermannova, Olga Bezlepkina, Jan Lebl, Agata Zygmunt-Gorska, Ondrej Cinek, Valentina Peterkova, Werner F. Blum, Herwig Frisch, Christopher J. Child, Rasa Verkauskiene, Natalija Smetanina, Jerzy Starzyk   +12 more
core   +1 more source

Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C). [PDF]

, 1998
As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in the development and organogenesis of this gland may account for a form of combined pituitary hormone deficiency (CPHD).
Wu, W., Mullis, P. E., Deladoey, J., Flück, Christa, Eblé, A., Marti, U., Rutishauser, K.   +6 more
core   +1 more source

"Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency.

, 1999
As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in the development and organogenesis of this gland may account for a form of combined pituitary hormone deficiency (CPHD).
Büyükgebiz, A., Kuhlmann, B. V., Fluck, C, Deladoey, J, Mullis, PE, Kuhlmann, BV, Buyukgebiz, A, Hindmarsh, PC, Eblé, Andrée, Wu, W., Flück, Christa, Wu, W, Mullis, Primus-Eugen, Hindmarsh, P. C., Eble, A, Deladoëy, Johnny, Flück Pandey, Christa Emma   +16 more
core   +1 more source