Results 81 to 90 of about 2,015 (159)

Toxoplasma gondii PROP1 is critical for autophagy and parasite viability during chronic infection

mSphere
Macroautophagy is an important cellular process involving lysosomal degradation of cytoplasmic components, facilitated by autophagy-related proteins.
Pariyamon Thaprawat, Fengrong Wang, Shreya Chalasani, Tracey L. Schultz, Manlio Di Cristina, Vern B. Carruthers   +5 more
doaj   +1 more source

转基因植物表达质粒中SBR 基因的序列分析

Zhongshan Daxue xuebao. Yixue kexue ban, 2001
【目的】对转基因植物表达质粒pROP1 中含SBR 基因P1 片段(184 ～ 1946 bp)进行序列测定和分析。【方法】从 E .coli DH5α中提取质粒pROP1, 用PCR 测序试剂盒和DNA 自动测序仪检测P1 片段的序列, 并与GenBank 上的变形链球菌 表面蛋白基因序列比较, 检测其准确性。【结果】测定了P1 片段5′端616 个碱基序列和3′端466 个碱基序列, 其准确性达 98 %。【结论】PCR 扩增的P1 片段5′端和3′端的DNA 序列与变形链球菌表面蛋白pac ...
蒋少云, 凌均
doaj  

Mutation analysis of POUF-1, PROP1 and HESX1 show low frequency of mutations in children with combined pituitary hormone deficiency and septo-optic dysplasia

, 2005
OBJECTIVES: Mutations in the genes encoding the transcription factors PROP1 and POUF-1 (Pit-1) have been reported as common causes of combined pituitary hormone deficiency (CPHD), and HESX1 mutations have been identified in children with septo-optic ...
Cole, Trevor, Rainbow, Lynne, Barrett, Timothy; id_orcid, Shaw, Nicholas, Kirk, Jeremy, Shaikh, G, Rainbow, L.A., Cole, T., Barrett, T.G., Kirk, J.M.W., Shaw, N.J., Rees, S.A., Shaikh, M.G.   +12 more
core   +1 more source

Analysis of PROP1 and CTNNB1 expression genes in adamantinomatous craniopharyngiomas with and without CTNNB1 somatic mutation

, 2010
Os craniofaringiomas são os tumores mais frequentes da região hipotálamohipofisária na faixa etária pediátrica. Apesar de serem histologicamente benignos, sua tendência infiltrativa e seu comportamento agressivo resultam em significante morbimortalidade.
Cani, Carolina Maria Gomes, Carolina Maria Gomes Cani   +1 more
core   +1 more source

Evaluating the serological applications of Toxoplasma gondii rhoptry protein 1 (ROP1) antigen

Journal of Basic Research in Medical Sciences, 2017
Introduction: Toxoplasma gondii (T. gondii) is distributed worldwide and infects most species. The serious incidence and severe or fatal injury caused by T. gondii infection clearly indicates the necessity for the event of a vaccine.
Fatemeh Keshavarzi, Parviz Ashtari, Pirooz Ebrahimi   +2 more
doaj  

Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study

, 2015
PubMedID: 25500790To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients with CPHD were included in this study.
Çetinkaya E., Uyguner Z.O., Darendeliler F., Berberoğlu M., Aycan Z., Şiklar Z., Baş F.   +6 more
core   +1 more source

Generation of a prop1 knock-in zebrafish enables single-cell transcriptomics of early pituitary development

The adenohypophyseal placode is a developmental structure that is conserved among vertebrates and gives rise to the anterior pituitary. The earliest steps of its formation remain poorly understood.
Martinez-Mayer, J., Perez-Millan, M., Medan, V., Balakrishnan, M., Gunther, S., Stainier, D., Cheung, L.   +6 more
core   +1 more source

Frequency of mutations in PROP-1 gene in Turkish children with combined pituitary hormone deficiency

The Turkish Journal of Pediatrics, 2012
Mutations in the prophet of Pit-1 (PROP-1) gene are responsible for most of the cases of combined pituitary hormone deficiencies (CPHD). We performed this study to determine the prevalence of PROP-1 mutations in a group of Turkish children with ...
Nurgün Kandemir, Doğuş Vurallı, Ekim Taşkıran, Nazlı Gönç, Alev Özön, Ayfer Alikaşifoğlu, Engin Yılmaz   +6 more
doaj  

Pituitary magnetic resonance Imaging in 15 patients with Prop1 gene mutations: Pituitary enlargement may originate from the intermediate lobe

, 2004
Pituitary morphology in patients with Prop1 gene mutations varies. Most patients demonstrate a normal or small pituitary gland. Occasionally, pituitary enlargement of undetermined origin has also been detected.
Maniati-Christidi, M, Xekouki, P, Patronas, N, Bossis, I, Thalassinos, N, Livadas, S, Sertedaki, A, Voutetakis, D, Argyropoulou, M, Voutetakis, A, Dacou-Voutetakis, C   +10 more
core   +2 more sources

Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD)

, 2005
The definitive version is available at www.blackwell-synergy.comObjective Mutations within the pituitary-specific paired-like homeobox gene PROP1 have been described in 50–100% of patients with familial combined pituitary hormone deficiency (CPHD).
Tiulpakov, A., Tiulpakov, Anatoly, Raza, Jamal, Dattani, Mehul T., Thomas, P., Ammini, A., Mehta, A., Chong, K., Mehta, Ameeta, Bouloux, Pierre M., Woods-Townsend, Kathryn, Bouloux, P., Turton, J., Eunice, Marumudi, Thomas, Paul Q., Cassar, Joseph, Chong, Kling, Turton, James P.G., Ammini, Ariachery C., Eunice, M., Woods, K., Raza, J., Hindmarsh, Peter C., Cassar, J., Hindmarsh, P., Starzyk, Jerzy, Starzyk, J., Dattani, M.   +27 more
core   +1 more source