Results 11 to 20 of about 2,015 (159)
PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells [PDF]
eLife, 2016 Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its mechanism of action is highly relevant from a therapeutic perspective.
María Inés Pérez Millán +3 more
doaj +2 more sources
A Large PROP1 Gene Deletion in a Turkish Pedigree [PDF]
Case Reports in Endocrinology, 2018 Pituitary-specific paired-like homeodomain transcription factor, PROP1, is associated with multiple pituitary hormone deficiency. Alteration of the gene encoding the PROP1 may affect somatotropes, thyrotropes, and lactotropes, as well as gonadotropes and
Suheyla Gorar +2 more
doaj +2 more sources
Clinics, 2011 INTRODUCTION: Activating mutations in exon 3 of the β-catenin gene are involved in the pathogenesis of adamantinomatous craniopharyngiomas. Recently, the interaction between β-catenin and PROP1 has been shown to be responsible for pituitary ...
Carolina M.G Cani +6 more
doaj +2 more sources
Frontiers in Endocrinology, 2017 BackgroundHypopituitarism as a result of PROP1 (prophet of PIT1) mutation represents the most common genetic cause of combined deficiency of pituitary hormones and due to growth retardation it is typically diagnosed in childhood.Case descriptionWe ...
Ludmila Brunerova +5 more
doaj +2 more sources
A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. [PDF]
PLoS ONE, 2009 BackgroundThe adult endocrine pituitary is known to host several hormone-producing cells regulating major physiological processes during life. Some candidates to progenitor/stem cells have been proposed.
Montse Garcia-Lavandeira +10 more
doaj +2 more sources
Growth Hormone Receptor Antagonism Extends Lifespan. [PDF]
Aging CellThis study provides proof of concept that GH antagonism in GH‐producing mice extends lifespan, supporting further investigation of GH antagonists as potential anti‐aging interventions in animals and humans. ABSTRACT Interventions that disrupt growth hormone (GH) action are recognized as some of the most potent methods for extending lifespan ...
List EO +5 more
europepmc +2 more sources
The role of
, 2005 Growth insufficiency occurs once in every 4000 live births and commonly results from deficits in pituitary hormones. PROP1 is one of several homeodomain transcription factors that are required for the development of the hormone producing cell types of ...
Ward, Robert D.
core +5 more sources
Kallmann Syndrome in a 30-Year-Old Female With Primary Infertility: A Case Report. [PDF]
Case Rep Obstet GynecolKallmann syndrome (KS) is a rare genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. This case report highlights a 30‐year‐old woman with KS who presented with secondary amenorrhea and uterine hypoplasia after repeated use of combined oral contraceptives (COCs).
Soryadharma A, Ritonga MA, Permadi W.
europepmc +2 more sources
Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 years post-discovery
Archives of Endocrinology and Metabolism, 2019 The first description of patients with combined pituitary hormone deficiencies (CPHD) caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and genetic characteristics of patients with PROP1 mutations and summarized the phenotypes
Fernanda A. Correa +8 more
doaj +1 more source
SEMA3A and IGSF10 Are Novel Contributors to Combined Pituitary Hormone Deficiency (CPHD)
Frontiers in Endocrinology, 2020 Background: The mutation frequencies of pituitary transcription factors genes in patients with combined pituitary hormone deficiencies (CPHD) vary substantially between populations.
Bartlomiej Budny +16 more
doaj +1 more source