Results 121 to 130 of about 746,495 (300)

Comparison of Operational and Economic Aspects of Direct Road Transport and Continental Combined Transport

, 2017
The aim of this paper is to compare economic and operational aspects in the transition from direct road transport to unaccompanied CT using intermodal road semitrailers.
Jozef Gasparik, Jaromir Siroky, Stephan Schroder   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

METHOD OF CALCULATING A COMBINED TRANSPORT SYSTEM [PDF]

Annals of the University of Petroşani. Mechanical Engineering
In the specialized literature, efforts have been made to define multimodal transport. Thus, multimodal transport refers to the transportation of goods carried out using at least two different modes of transport, based on a multimodal transport contract ...
Ildiko Brinas
doaj  

Use of U.S. submarines to transport vital supplies.

, 2008
This addresses the problem of the transport of vital supplies from Cebu City to Corregidor through the Japanese naval blockade of Manila ...
Wood, S.
core  

Transport impacts on land use : towards a practical understanding for urban policy making [PDF]

, 1997
The premise of this study was that transport impacts on land use are rarely given formal or adequate consideration in the strategic planning system in the UK. Therefore, this research examined current attitudes to transport impacts on land use, amongst a
Still, Benjamin Gordon, Benjamin Gordon Still   +1 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Armed helicopter escort of transport helicopters.

, 2008
This report presents armed helicopter tactics and survivability data that were documented and collected during counterinsurgency operations in Vietnam. Most of the data presented concern missions in which armed helicopters escorted transport helicopters ...
Army Concept Team in Vietnam
core  

Optimizing sales areas of combined transport chains

, 2013
Background: Combined transport chains (such as intermodal transport), have certain advantages. The main advantage from customer points of view is the possibility to bundle freight and thereby decrease transport costs.
Michalk, Philip
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source