Estimation of heterosis, combining ability and reciprocal effects for body weight in four genetic groups of chicken from a full diallel cross. [PDF]
Teshome P, Goshu G, Esatu W, Dessie T.
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Exploring molecular variation and combining ability of local and exotic bread wheat genotypes under well-watered and drought conditions. [PDF]
Motawei MI, Kamara MM, Rehan M.
europepmc +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Combining ability analysis of Cucurbita moschata D. in Côte d'Ivoire and classification of promising lines based on their gca effects. [PDF]
Kouago BA +6 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Inheritance of Some Salt Tolerance-Related Traits in Bread Wheat (<i>Triticum aestivum</i> L.) at the Seedling Stage: A Study of Combining Ability. [PDF]
Hadji T +9 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Increasing jute (<i>Corchorus olitorius</i> L.) fiber yield through hybridization and combining ability studies to break the yield plateau. [PDF]
Chourasia KN +10 more
europepmc +1 more source

