Results 161 to 170 of about 2,441,843 (293)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Combining ability and gene action for flowering, plant height, grain size, and yield in rice (<i>Oryza sativa L</i>.) genotypes. [PDF]

Front Plant Sci
Jeke E, Bokosi J, Murori R, Asante MD, Masamba K.   +4 more
europepmc   +1 more source

Combining Ability and Reciprocal Effects for the Yield of Elite Blue Corn Lines from the Central Highlands of Mexico. [PDF]

Plants (Basel), 2023
Arellano-Vázquez JL, Gutiérrez-Hernández GF, Ceja-Torres LF, Flores-Gómez E, García-Ramírez E, Quiroz-Figueroa FR, Vázquez-Lozano P.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genetic Trends in General Combining Ability for Maize Yield-Related Traits in Northeast China. [PDF]

Curr Issues Mol Biol
Wang H, Zhang X, Weng J, Li M, Hao Z, Zhang D, Yong H, Han J, Zhou Z, Li X.   +9 more
europepmc   +1 more source

Combining ability analysis of yield and biomass allocation related traits in newly developed wheat populations. [PDF]

Sci Rep, 2023
Shamuyarira KW, Shimelis H, Figlan S, Chaplot V.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exploitation of combining ability and heterotic potential of okra under the sub-mountain region of Himalayan. [PDF]

Sci Rep
Pathania R, Singh A, Mehta DK, Bhardwaj RK, Tariq M, Garg S, Jain M, Mohammed A, Gangola S, Mittal A.   +9 more
europepmc   +1 more source

Evaluation of salinity resistance and combining ability analysis in the seedlings of mulberry hybrids (Morus alba L.). [PDF]

Physiol Mol Biol Plants, 2023
Chen X, Gao Y, Zhang D, Gao Y, Song Y, Wang H, Ma B, Li J.   +7 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source