Results 151 to 160 of about 778,102 (310)
Assessment of combining ability for grain yield and its attributing traits in maize (Zea mays L.)
Discover AgricultureA comprehensive understanding of combining ability is an emerging focus in hybrid maize research in Nepal. The present study aimed to evaluate the performance of single-cross maize hybrids and to estimate the combining abilities of parental lines for ...
Jiban Shrestha +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Combining ability of grain sorghum lines selected for aluminum tolerance
, 2014 The purpose of this study was to estimate combining ability of 58 sorghum lines previously selected for Aluminum (Al) tolerance. One hundred sixty-five hybrids were evaluated at three levels of Al saturation (0%, 20% and 50%) at the same season.
Costa Bernardino, Karine +6 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Combining ability in eight selected clones of sugarcane (Saccharum sp)
Crop Breeding and Applied Biotechnology, 2002 Eight commercial sugarcane (Saccharum sp) clones were crossed in a full diallel. Five characters were evaluated in the progeny in one or two harvests: Refractometer solids (Brix %), Yield (tons of cane per hectare, TCH), number of millable stalks ...
José Antonio Bressiani +4 more
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
STUDY OF COMBINING ABILITY OF NEW SELF-POLLINATED LINES OF MAIZE IN CENTRAL PART OF KRASNODAR KRAI
Зерновое хозяйство России, 2018 It’s common knowledge that any success of breeding work largely depends on initial material. The staff of Krasnodar RIA named after P.P. Lukiyanenko is carrying out a significant work in breeding, assessment and classification of new initial material for
I. M. Chilashvili +2 more
doaj