Results 101 to 110 of about 81,496 (301)

Overexpressed Palladin Rescues Enteropathogenic E. coli (EPEC) Pedestal Lengths in ArpC2 Depleted Cells

Cytoskeleton, EarlyView.
ABSTRACT Enteropathogenic Escherichia coli (EPEC) causes diarrheal disease. Once ingested, these extracellular pathogens attach to the intestinal epithelial cells of their host, collapse the localized microvilli, and generate actin‐rich structures within the host cells that are located beneath the attached bacteria, called “pedestals.” Palladin is an ...
Kaitlin M. Bruzzini, S. Tara Mann, Julian A. Guttman   +2 more
wiley   +1 more source

Transforming a Historical Chemical Synthetic Route for Vanillin Starting from Renewable Eugenol to a Cell‐Free Bi‐Enzymatic Cascade

ChemSusChem, EarlyView.
An artificial enzymatic cascade to access natural vanillin from eugenol/clove oil was developed by revisiting the very first vanillin synthetic process from 19th century. The biosynthetic route consists of just two biocatalysts used as cell‐free preparation and molecular oxygen as oxidizing agent, outperforming also the natural microbial pathway which ...
Elisa Lanfranchi, Valerio Ferrario, Somayyeh Gandomkar, Stefan E. Payer, Erna Zukic, Haris Rudalija, Alexandra Musi, Ines Gaberscek, Yuliya Orel, Doreen Schachtschabel, Christian Willrodt, Michael Breuer, Wolfgang Kroutil   +12 more
wiley   +1 more source

Molecular profiles of single circulating tumor cells from early breast cancer patients with different lymph node statuses

Thoracic Cancer, Volume 14, Issue 2, Page 156-167, January 2023., 2023
Circulating tumor cells (CTCs) were clustered into two subtypes significantly correlated with the lymph node metastasis status of early breast cancer patients. Patients with lymph node metastasis have CTCs that express an epithelial/stem‐like pattern of metastasis initiating cells, while those patients without lymph node metastasis have CTCs that have ...
Shuyun Pang, Shu Xu, Lulu Wang, Haiping Wu, Yanan Chu, Xueping Ma, Yujiao Li, Bingjie Zou, Shaohua Wang, Guohua Zhou   +9 more
wiley   +1 more source

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

Drug Testing and Analysis, EarlyView.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel, Sylvia E. Escher, Emanuel Weiler, Anke Londenberg, Uwe Deppenmeier, Rhys Whomsley   +5 more
wiley   +1 more source

DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection

Aging Cell, Volume 21, Issue 12, December 2022., 2022
Our data suggest DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection and provide a novel target for anti‐viral intervention. Abstract Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is known to disproportionately affect older individuals.
Rui Jin, Chang Niu, Fengyun Wu, Sixin Zhou, Tao Han, Zhe Zhang, Entao Li, Xiaona Zhang, Shanrong Xu, Jiadong Wang, Shen Tian, Wei Chen, Qinong Ye, Cheng Cao, Long Cheng   +14 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Les dispositifs de confiance utilisés par les petites entreprises du bâtiment en France [PDF]

Journal of Social Research & Policy, 2010
Small construction companies mobilize different kinds of confidence for capturing and reassure their customers. Beyond the interpersonal networks, the most common device, they create devices such as professional qualifications and certifications, and ...
Catherine Comet
doaj  

Synthesis of global satellite observations of magmatic and volcanic deformation: implications for volcano monitoring & the lateral extent of magmatic domains

Journal of Applied Volcanology, 2018
Global Synthetic Aperture Radar (SAR) measurements made over the past decades provide insights into the lateral extent of magmatic domains, and capture volcanic process on scales useful for volcano monitoring.
S. K. Ebmeier, B. J. Andrews, M. C. Araya, D. W. D. Arnold, J. Biggs, C. Cooper, E. Cottrell, M. Furtney, J. Hickey, J. Jay, R. Lloyd, A. L. Parker, M. E. Pritchard, E. Robertson, E. Venzke, J. L. Williamson   +15 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source