Results 81 to 90 of about 164,599 (350)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Extension of Tian Shan along a nascent shear zone

Nature Communications
Our understanding of the dynamics of mountain belt growth is hampered by the lack of high-resolution kinematic observations spanning entire orogenic belts. This is particularly the case for the structurally complex and nascent Tian Shan plateau.
Qi Ou, John R. Elliott, Yasser Maghsoudi, Chris Rollins, Milan Lazecky, Tim J. Wright   +5 more
doaj   +1 more source

The European Space Agency’s Comet Interceptor lies in wait

Nature Communications, 2019
The European Space Agency (ESA) recently selected Comet Interceptor as its first ‘fast’ (F-class) mission. It will be developed rapidly to share a launch with another mission and is unique, as it will wait in space for a yet-to-be-discovered comet.
C. Snodgrass, G. Jones
semanticscholar   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Strain Partitioning in the Southeastern Tibetan Plateau From Kinematic Modeling of High‐Resolution Sentinel‐1 InSAR and GNSS

Geophysical Research Letters
Fault slip rates estimated from geodetic data are being integrated into seismic hazard models. The standard approach requires modeling velocities and relative (micro‐)plate motions, which is challenging for fault‐based models.
Jin Fang, Tim J. Wright, Kaj M. Johnson, Qi Ou, Richard Styron, Tim J. Craig, John R. Elliott, Andy Hooper, Gang Zheng   +8 more
doaj   +1 more source

Thermalisme et villégiature autour d’Auch

Les Cahiers de Framespa, 2021
Around Auch, in the mid-19th century, several hot springs were exploited. Small thermal establishments were set up there, but not all of them gave rise to real spas as in Castéra-Verduzan.
Anaïs Comet
doaj   +1 more source

Evidence for the formation of comet 67P/Churyumov-Gerasimenko through gravitational collapse of a bound clump of pebbles [PDF]

, 2017
The processes that led to the formation of the planetary bodies in the Solar system are still not fully understood. Using the results obtained with the comprehensive suite of instruments onboard the European Space Agency's Rosetta mission, we present ...
J. Blum, B. Gundlach, M. Krause, M. Fulle, A. Johansen, J. Agarwal, I. von Borstel, Xian Shi, Xuanyu Hu, M. Bentley, F. Capaccioni, L. Colangeli, V. Della Corte, N. Fougere, S. Green, S. Ivanovski, T. Mannel, S. Merouane, A. Migliorini, A. Rotundi, R. Schmied, C. Snodgrass   +21 more
semanticscholar   +1 more source

Volatile Species in Comet 67P/Churyumov-Gerasimenko: Investigating the Link from the ISM to the Terrestrial Planets [PDF]

ACS Earth and Space Chemistry, 2019
Comets contain abundant amounts of organic and inorganic species. Many of the volatile molecules in comets have also been observed in the interstellar medium and some of them even with similar relative abundances, indicating formation under similar ...
M. Rubin, D. Bekaert, M. Broadley, M. Drozdovskaya, S. Wampfler   +4 more
semanticscholar   +1 more source

The Comet Interceptor mission to a dynamically new comet

, 2023
openL'elaborato mira ad affrontare il problema del tipo di manovre orbitali richieste per lo scopo della missione Comet Interceptor, ovvero il raggiungimento di un fly-by attorno a una cometa dinamicamente nuova proveniente dalla regione esterna al ...
SIMULA, SUSANNA
core  

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source