Results 71 to 80 of about 264,390 (347)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Strain Partitioning in the Southeastern Tibetan Plateau From Kinematic Modeling of High‐Resolution Sentinel‐1 InSAR and GNSS

Geophysical Research Letters
Fault slip rates estimated from geodetic data are being integrated into seismic hazard models. The standard approach requires modeling velocities and relative (micro‐)plate motions, which is challenging for fault‐based models.
Jin Fang, Tim J. Wright, Kaj M. Johnson, Qi Ou, Richard Styron, Tim J. Craig, John R. Elliott, Andy Hooper, Gang Zheng   +8 more
doaj   +1 more source

Observing eruptions of gas-rich compressible magmas from space

Nature Communications, 2016
Satellite observations are an important tool in volcano monitoring, but observations such as ground deformation and gas emissions are treated independently. Here, the authors present a model coupling them through their link to magma volatile contents and
Brendan McCormick Kilbride, Marie Edmonds, Juliet Biggs   +2 more
doaj   +1 more source

The extraordinary composition of the blue comet C/2016 R2 (PanSTARRS) [PDF]

Astronomy & Astrophysics, 2018
We present a multi-wavelength study of comet C/2016 R2 (PanSTARRS). This comet was observed on 23 and 24 January 2018 with the IRAM 30 m telescope, and in January to March 2018 with the Nançay radio telescope.
N. Biver, D. Bockel'ee-Morvan, G. Paubert, R. Moreno, J. Crovisier, J. Boissier, E. Bertrand, H. Boussier, F. Kugel, A. McKay, N. Russo, M. DiSanti   +11 more
semanticscholar   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

An investigation of changes to commercial aircraft flight paths during volcanic eruptions

Journal of Applied Volcanology
Volcanic eruptions can inject ash into the atmosphere, which is then advected by meteorological winds, potentially affecting large volumes of airspace. Volcanic Ash Advisory Centres (VAACs) issue volcanic ash advisories (VAAs) when airspace is likely to ...
Juliette Delbrel, Mike Burton, Samantha Engwell, Benjamin Esse, Catherine Hayer   +4 more
doaj   +1 more source

Thermalisme et villégiature autour d’Auch

Les Cahiers de Framespa, 2021
Around Auch, in the mid-19th century, several hot springs were exploited. Small thermal establishments were set up there, but not all of them gave rise to real spas as in Castéra-Verduzan.
Anaïs Comet
doaj   +1 more source

The nucleus of 103P/Hartley 2, target of the EPOXI mission

, 2010
103P/Hartley 2 was selected as the target comet for the Deep Impact extended mission, EPOXI, in October 2007. There have been no direct optical observations of the nucleus of this comet, as it has always been highly active when previously observed.
C. Snodgrass, Groussin, Jewitt, K. Meech, Lamy, Licandro, Lisse, Lowry, Lowry, Mazzotta Epifani, Meech, O. Hainaut, Snodgrass, Snodgrass, Snodgrass   +14 more
core   +1 more source

Krypton isotopes and noble gas abundances in the coma of comet 67P/Churyumov-Gerasimenko [PDF]

Science Advances, 2018
Noble gases in comet 67P/Churyumov-Gerasimenko indicate nonhomogenized protoplanetary disk material at its location of formation. The Rosetta Orbiter Spectrometer for Ion and Neutral Analysis mass spectrometer Double Focusing Mass Spectrometer on board ...
M. Rubin, K. Altwegg, H. Balsiger, A. Bar-Nun, J. Berthelier, C. Briois, U. Calmonte, M. Combi, J. de Keyser, B. Fiethe, S. Fuselier, S. Gasc, T. Gombosi, K. Hansen, E. Kopp, A. Korth, D. Laufer, L. Le Roy, U. Mall, B. Marty, O. Mousis, T. Owen, H. Rème, T. Sémon, C. Tzou, J. Waite, P. Wurz   +26 more
semanticscholar   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source