Results 261 to 270 of about 225,144 (339)

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

open access: yesThe FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li   +7 more
wiley   +1 more source

Corrigendum: Nickel oxide nanoparticles exposure as a risk factor for male infertility: “In vitro” effects on porcine pre-pubertal Sertoli cells

open access: yesFrontiers in Endocrinology
Iva Arato   +16 more
doaj   +1 more source

CDKL5 regulates the initiation of retrograde axonal transport through CLIP170–dynactin complex formation

open access: yesThe FEBS Journal, EarlyView.
Activation of CLIP170 by CDKL5 in wild‐type (WT) cells promotes its open conformation and association with tyrosinated microtubule (MT) plus‐ends (+), where it works as a docking site to recruit the dynactin–dynein–cargo complex, promoting the initiation of retrograde transport. In knock‐out (KO) neurons, CLIP170 is mainly present in a closed (inactive)
Serena Baldin   +4 more
wiley   +1 more source

DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study. [PDF]

open access: yesMutagenesis
Cabral JV   +8 more
europepmc   +1 more source

Older Adults' Self‐Care and Family Caregiver Contribution in Multiple Chronic Conditions: A Dyadic Qualitative Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore how older adult‐family caregiver dyads jointly manage multiple chronic conditions. Specifically, it investigates how dyads (i) prioritise chronic diseases, (ii) make and negotiate decisions related to self‐care and (iii) define and distribute self‐care tasks and caregiver contributions.
Giulia Andrea Baldan   +6 more
wiley   +1 more source

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