Results 71 to 80 of about 229,895 (346)

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Solar wind interaction with comet 67P: impacts of corotating interaction regions [PDF]

, 2016
International audienceWe present observations from the Rosetta Plasma Consortium of the effects of stormy solar wind on comet 67P/Churyumov-Gerasimenko. Four corotating interaction regions (CIRs), where the first event has possibly merged with a coronal ...
Andrews, DJ, Burch, JL, Carr, CM, Cupido, E, Edberg, NJT, Eriksson, AI, Glassmeier, KH, Goldstein, R, Halekas, JS, Henri, P, Johansson, F, Koenders, C, Mandt, K, Mokashi, P, Nemeth, Z, Nilsson, H, Odelstad, E, Ramstad, R, Richter, I, Stenberg Wieser, G, Vigren, E   +20 more
core   +3 more sources

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Fabry's Comet and Barnard's Comet [PDF]

Nature, 1886
NOT having seen any mention of the rapid apparent growth of the tail of Fabry's comet, probably some of your readers are not aware to how great a length it extended. On April 26 occurred the first fine night after a very unusual series of overcast ones, and about 14h. G.M.T. I was surprised to see the tail reaching up to, or at least to within 1° of δ,
openaire   +1 more source

Solar-insolation-induced changes in the coma morphology of comet 67P/Churyumov-Gerasimenko. Optical monitoring with the Nordic Optical Telescope [PDF]

, 2017
Context. 67P/Churyumov-Gerasimenko (67P/C-G) is a short-period Jupiter family comet with an orbital period of 6.55 years. Being the target comet of ESA’s Rosetta mission, 67P/C-G has become one of the most intensively studied minor bodies of the Solar ...
A. Somero, Accomazzo, B. Zaprudin, Boehnhardt, C. Snodgrass, H. J. Lehto, Hadamcik, K. Nilsson, Knollenberg, Langevin, Merouane, Moreno, Preusker, R. Schulz, Schulz, Sekanina, Snodgrass, T. Pursimo, Vincent, Vincent, Weiler, Zaprudin   +21 more
core   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

COMET: Coverage-guided Model Generation For Deep Learning Library Testing [PDF]

, 2022
Meiziniu Li, Jialun Cao, Yongqiang Tian, Tsz On Li, Ming Wen, Shing-Chi Cheung   +5 more
openalex   +1 more source

GALEX FUV Observations of Comet C/2004 Q2 (Machholz): The Ionization Lifetime of Carbon

, 2010
We present a measurement of the lifetime of ground state atomic carbon, C(^3P), against ionization processes in interplanetary space and compare it to the lifetime expected from the dominant physical processes likely to occur in this medium.
Axford, Bockelée-Morvan, Bonev, Combi, Combi, Eberhardt, Feldman, Festou, Glinski, Harold A. Weaver, Harris, Haser, Hibbert, Jeffrey P. Morgenthaler, Kobayashi, Krishna-Swamy, Kupperman, Lupu, Markwardt, Martin, McPhate, Michael R. Combi, Morrissey, Morrissey, Moré, Paul D. Feldman, Sujatha, Tozzi, van Dishoeck, Walter M. Harris   +29 more
core   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source