Results 81 to 90 of about 225,144 (339)

Cometary impacts into ocean: Thermodynamical equilibrium calculations of high-temperature O2 generation on the early Earth [PDF]

Journal of the Serbian Chemical Society, 2002
The early Earth’s atmosphere apparently differed from the present atmosphere mainly in its lack of free O2, and this absence is believed to have been indispensable for the origin of early anaerobic life forms. One of the central problems in Earth science
Premović Pavle I., Panov Katja I.
doaj   +1 more source

Dimer‐Specific FokT‐seq Reveals DNA‐Binding Dimerization and Novel Genomic Targets of TDP‐43

Advanced Science, EarlyView.
Loss of TDP‐43 dimerization is implicated in ALS, yet its mechanistic role remains elusive. This study introduces FokT, a novel system that restores TDP‐43 dimerization to map its DNA targets via FokT‐seq. The findings uncover key binding sites and offer a versatile tool for exploring dimer‐dependent transcriptional regulation.
Mingming Yang, Qi Wang, Ruolan Yan, Xiaochuan Wang, Jianlan Gu   +4 more
wiley   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source

Spatial distribution of low-energy plasma around 2 comet 67P/CG from Rosetta measurements [PDF]

, 2015
International audienceWe use measurements from the Rosetta plasma consortium (RPC) Langmuir probe (LAP) and mutual impedance probe (MIP) to study the spatial distribution of low-energy plasma in the near-nucleus coma of comet 67P/Churyumov-Gerasimenko ...
A. I. Eriksson, C. Koenders, C. M. Carr, E. Cupido, E. Odelstad, E. P. G. Johansson, E. Vigren, F. Johansson, G. Stenberg Wieser, H. Nilsson, Haser L., I. Richter, J. E. Wahlund, J.‐P. Lebreton, K. Mandt, K. Szego, K.‐H. Glassmeier, M. André, M. Rubin, M. Volwerk, N. J. T. Edberg, P. Henri, R. Gill, R. Goldstein, S. Gasc, Z. Nemeth   +25 more
core   +6 more sources

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Frozen to death? -- Detection of comet Hale-Bopp at 30.7 AU

, 2011
Comet Hale--Bopp (C/1995 O1) has been the single most significant comet encountered by modern astronomy, still having displayed significant activity at 25.7 AU solar distance in late 2007.
A’Hearn, Bilir, Caldwell, Capria, Eddington, Gy. M. Szabó, Hainaut, Ivanova, Jewitt, K. Sárneczky, L. L. Kiss, Landolt, Lowry, Lowry, Lowry, Lowry, Mazzotta Epifani, Mazzotta Epifani, Mazzotta Epifani, Meech, Meech, Rousselot, Snodgrass, Snodgrass, Szabó, Szabó, Szabó, Szabó, Weaver, West   +29 more
core   +1 more source

In Situ Structural Evolution and Activity Descriptor of Atomically Dispersed Catalysts During Nitrate Electroreduction

Advanced Science, EarlyView.
The in situ evolution of single‐atom catalysts to metallic nanoclusters during nitrate electroreduction is demonstrated. A direct correlation between the OH binding energy on the metallic clusters and ammonia production rate is established as a key activity descriptor, explaining the superior performance of Ni and Co catalysts.
Daniel S. Braga, Angus Pedersen, Mohd Riyaz, Jesús Barrio, Alexander Bagger, Itamar T. Neckel, Thiago M. Mariano, Manuel E. G. Winkler, Ifan E. L. Stephens, Maria‐Magdalena Titirici, Raphael Nagao   +10 more
wiley   +1 more source

The problem of the abolition of slavery and maritime rights on U.S. vessels with regards to British American relations in the first half of the 19th century

Przegląd Nauk Historycznych, 2020
The article analyses the struggle of Anglo-American relations connected to slaves and maritime rights on the sea from 1831 to 1842. The study is based on monographs, reports, treaties and correspondences between the two countries from the explosion of ...
Nguyen Van Sang, Jolanta A. Daszyńska
doaj   +1 more source

Detailed opacity calculations for astrophysical applications

, 2017
Nowadays, several opacity codes are able to provide data for stellar structure models, but the computed opacities may show significant differences. In this work, we present state-of-the-art precise spectral opacity calculations, illustrated by stellar ...
Comet, Maxime, Gilleron, Franck, Pain, Jean-Christophe   +2 more
core   +2 more sources

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

Advanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng   +10 more
wiley   +1 more source