Results 81 to 90 of about 3,231,447 (290)

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

Clinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit, Maaike van Dartel, Laura Rodwell, Hanneke van der Woude, Cornelis Boersma, Peter G. M. Mol, Doranne Hilarius   +6 more
wiley   +1 more source

A Large Outburst, Coma Asymmetries, and the Color of Comet 243P/NEAT

The Planetary Science Journal
Water ice is a fundamental building material of comets and other bodies in the outer solar system. Yet the properties of cometary water ice are challenging to study, due to its volatility and the typical distances at which comets are observed.
Michael S. P. Kelley, Silvia Protopapa, Dennis Bodewits, Aren N. Heinze, Youssef Moulane, Quanzhi Ye, Bryce Bolin, Simon Conseil, Tony L. Farnham, Lori Feaga, Xing Gao, Chih-Hao Hsia, Emmanuel Jehin, Shrinivas R. Kulkarni, Russ R. Laher, Tim Lister, Frank J. Masci, Josiah Purdum, Bin Yang   +18 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Comet Assay alkalmazása a növényi sejteknél

, 2011
A főleg állati sejteknél alkalmazott Comet Assay módszerét mutatja be a szakdolgozat növényi sejtekre vonatkozóan, három típuskísérlettel.
Czirják, Tamás
core  

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Dynamical Population of Comet Reservoirs

The Oort cloud and the scattered disk are the two primary reservoirs for long-period and short-period comets, respectively. In this review, we assess the known observational constraints on these reservoirs' properties and their formation. In addition, we discuss how the early orbital evolution of the giant planets generated the modern scattered disk ...
Kaib, Nathan A., Volk, Kathryn
openaire   +2 more sources

PCLS (Precision Cut Lung Slices) as a putative model for genotoxicity testing by application of the comet assay

, 2022
S.2Actually, precision cut lung slices are under extensive investigation to serve as a model for acute inhalation toxicology. Slices can be employed as an ex-vivo/in-vitro model as alternative method in the context of REACH and the 3Rs. Moreover, this in
Sewald, K., Ritter, D., Knebel, J., Switalla, S.   +3 more
core   +1 more source

From patient notes to prognostication: The revolutionary potential of event‐based foundation models in orthopaedics

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract The integration of artificial intelligence (AI)‐equipped tools into electronic health record (EHR) platforms may drive the evolution of orthopaedic diagnosis and decision‐making, leveraging big data to generate precise and context‐aware insights.
Alexander M. Bouterse, James A. Pruneski, Felix C. Oettl, Bálint Zsidai, Umile Giuseppe Longo, Thomas Tischer, Michael T. Hirschmann, Kristian Samuelsson   +7 more
wiley   +1 more source

Simulating a Steady-state Heliosphere

The Astrophysical Journal Supplement Series
Ever since the discovery of the solar wind, it has been understood that our solar system resides within a bubble of solar wind plasma that originates from the Sun.
Jacob Heerikhuisen, Eric J. Zirnstein, Nikolai V. Pogorelov   +2 more
doaj   +1 more source

Comparing the dynamics of Jupiter-family Comets and comet-like fireballs

Astronomy & Astrophysics
Context. Jupiter-family comets (JFCs), which originate from the Kuiper belt and scattered disk, exhibit low-inclination and chaotic trajectories due to close encounters with Jupiter. Despite their typically short incursions into the inner solar system, a notable number of them are on Earth-crossing orbits, with fireball networks detecting many objects ...
P. M. Shober, G. Tancredi, J. Vaubaillon, H. A. R. Devillepoix, S. Deam, S. Anghel, E. K. Sansom, F. Colas, S. Martino   +8 more
openaire   +6 more sources