A Dormant Captured Oort Cloud Comet Awakens: (18916) 2000 OG44
The Astrophysical Journal LettersWe report the discovery of activity emanating from (18916) 2000 OG _44 (alternately designated 1977 SD), a minor planet previously reported to be both an extinct comet and an asteroid on a cometary orbit. We observed 2000 OG _44 with a thin tail oriented
Colin Orion Chandler +4 more
doaj +1 more source
Thermal model of water and CO activity of Comet C/1995 O1 (Hale-Bopp) [PDF]
, 2011 An investigation of the activity of Comet C/1995 O1 (Hale-Bopp) with a thermophysical nucleus model that does not rely on the existence of amorphous ice is presented.
H.U. Keller +8 more
core +1 more source
MDL‐800–Induced Sirtuin 6 Activation Decreases Age‐Associated Osteoarthritis in Mice
Arthritis &Rheumatology, EarlyView.Objective Sirtuin 6 (SIRT6) is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of MDL‐800, a small molecule activator of SIRT6, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays
Cytoskeleton, EarlyView.ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz +2 more
wiley +1 more source
Carbon Speciation and Solubility in Silicate Melts
Geophysical Monograph Series, Page 179-194., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Natalia Solomatova +2 more
wiley +2 more sources
Comet Lesions in Patients with Pseudoxanthoma Elasticum
, 2015 Pseudoxanthoma elasticum (PXE) is a genetic multisystemic disorder affecting the skin, eyes and cardiovascular system. Basic fundoscopic findings in PXE result from Bruch’s membrane involvement.
Muhsin Altunsoy +2 more
core +1 more source
Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset
Clinical Pharmacology &Therapeutics, EarlyView.Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit +6 more
wiley +1 more source
A Large Outburst, Coma Asymmetries, and the Color of Comet 243P/NEAT
The Planetary Science JournalWater ice is a fundamental building material of comets and other bodies in the outer solar system. Yet the properties of cometary water ice are challenging to study, due to its volatility and the typical distances at which comets are observed.
Michael S. P. Kelley +18 more
doaj +1 more source
Dynamical Population of Comet Reservoirs
The Oort cloud and the scattered disk are the two primary reservoirs for long-period and short-period comets, respectively. In this review, we assess the known observational constraints on these reservoirs' properties and their formation. In addition, we discuss how the early orbital evolution of the giant planets generated the modern scattered disk ...
Kaib, Nathan A., Volk, Kathryn
openaire +2 more sources