Results 151 to 160 of about 535,368 (303)

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Doppler velocities in the ion tail of comet Levy 1990c [PDF]

We have obtained time alternating sequences of column density maps and Doppler velocity fields in the plasma tail of comet Levy 1990c.
Debi-Prasad, C., Geyer, E. H., Jockers, Klaus, Rauer, H.   +3 more
core   +1 more source

EPOXI Mission: Comet on a Stick [PDF]

, 2009
In this activity, students examine their concepts of a comet by designing and building a model. The goal is to have students replicate the scientific processes of observing, modeling, forming an explanation, making new observations, and revising. In this
John Risvey
core  

بررسی اثر ژنوپروتکتیو عصاره‌های آبی و متانولی اندام هوایی کرفس کوهی بر آسیب ناشی از ماده‌ی ژنوتوکسیک متیل متان سولفونات

مجله دانشکده پزشکی اصفهان, 2013
مقدمه: تخریب DNA به دنبال تماس با عوامل توکسیک گوناگون می‌تواند سبب افزایش خطر سرطان شود. گیاه کرفس کوهی یکی از گیاهان اندمیک ایران می‌باشد که مصرف خوراکی و دارویی دارد.
Mahmoud Etebari, Seyed Ebrahim Sajjadi, Abbas Jafarian-Dehkordi, Masumeh Panahi   +3 more
doaj  

Correlation of Solar Activity and Features in the Tail of Comet 1964 C [PDF]

, 1965
Michael F. A’Hearn
openalex   +1 more source

Overexpressed Palladin Rescues Enteropathogenic E. coli (EPEC) Pedestal Lengths in ArpC2 Depleted Cells

Cytoskeleton, Volume 82, Issue 8, Page 497-512, August 2025.
ABSTRACT Enteropathogenic Escherichia coli (EPEC) causes diarrheal disease. Once ingested, these extracellular pathogens attach to the intestinal epithelial cells of their host, collapse the localized microvilli, and generate actin‐rich structures within the host cells that are located beneath the attached bacteria, called “pedestals.” Palladin is an ...
Kaitlin M. Bruzzini, S. Tara Mann, Julian A. Guttman   +2 more
wiley   +1 more source

Cytology‐Radiology Correlation Series: Thyroid cytopathology

Cancer Cytopathology, Volume 133, Issue 8, August 2025.
Abstract Thyroid ultrasound is typically the first step in the workup of thyroid nodules. Ultrasonographic features of thyroid nodules can be used to evaluate their risk of malignancy using risk stratification systems to determine whether a nodule is suspicious enough to warrant a more invasive fine‐needle aspiration (FNA) for further evaluation.
Rachel Jug, Wen‐Chi Foo, Benjamin Wildman‐Tobriner, Xiaoyin “Sara” Jiang   +3 more
wiley   +1 more source

Imaging studies of comets [PDF]

Schmidt camera plates of comet Bradfield were secured on several nights in October 1987. The images of October 20 show the development of a huge bend in the plasma tail travelling several hundred kilometers per second down the tail; the likely solar-wind
Niedner, Malcolm B., Jr.
core   +1 more source

Reactive lymphoid hyperplasia of the liver: A case report featuring characteristic nodular and perinodular enhancement

Radiology Case Reports
A 53-year-old female with primary biliary cholangitis was referred for the evaluation of a hepatic nodule identified during routine imaging. Ultrasonography revealed a homogeneous, hypoechoic, 18 mm nodule in segment 3 of the liver. On dynamic CT and MRI,
Hirohito Osanai, MD, Kazuto Kozaka, MD, PhD, Norihide Yoneda, MD, PhD, Kotaro Yoshida, MD, PhD, Azusa Kitao, MD, PhD, Toshifumi Gabata, MD, PhD, Kenichi Harada, MD, PhD, Isamu Makino, MD, PhD, Satoshi Kobayashi, MD, PhD   +8 more
doaj  

Phloridzin as a Nutraceutical for Cancer Prevention and Therapy: A Comprehensive Review of Its Mechanisms, Bioavailability Challenges and Future Applications

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Phloridzin, a bioactive flavonoid from Malus species, demonstrates diverse therapeutic effects including anticancer, antidiabetic, hepatoprotective, cardioprotective, neuroprotective, and antimicrobial activities. Its anticancer efficacy is mediated through glucose transporter inhibition and modulation of oncogenic signaling pathways.
Praveen Dhyani, Priyanka Sati, Dharam Chand Attri, Eshita Sharma, Ruchi Soni, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source