Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes +6 more
wiley +1 more source
Two distinct populations of dark comets delineated by orbits and sizes. [PDF]
Seligman DZ +9 more
europepmc +1 more source
RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan +3 more
wiley +1 more source
Monitoring Beta-Blocker Therapy in Adolescents with Exercise-Induced Intraventricular Gradients Using Exercise Stress Echocardiography. [PDF]
Cotrim N +6 more
europepmc +1 more source
Modeling Whole-Body Dynamic PET Microdosing Data to Predict the Whole-Body Pharmacokinetics of Glyburide in Humans. [PDF]
Comin L +5 more
europepmc +1 more source
Alternation of must, have to, and need to in English as a lingua franca
Abstract This study explores the grammatical variability of modal auxiliary verbs in English as a lingua franca. Focusing on the ongoing change must, have to, and need to, this research utilizes two spoken corpora: the Vienna–Oxford International Corpus of English (VOICE) and the Asian Corpus of English (ACE).
Chunyuan Nie +2 more
wiley +1 more source
Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score. [PDF]
Hendrickx N +11 more
europepmc +1 more source
Maspin/SerpinB5 is a cytoskeleton-binding protein that regulates epithelial cell shape. [PDF]
da Silva LE +6 more
europepmc +1 more source

