Results 241 to 250 of about 53,221 (292)

Novel Drug‐Disease Modeling Framework for Oncology Benefit–Risk Evaluation: Application to Tusamitamab Ravtansine

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT This study introduces a novel drug‐disease modeling framework designed to assess the benefit–risk balance of antibody‐drug conjugates (ADC) in oncology. The framework integrates dose levels, pharmacokinetics, tumor growth dynamics, progression‐free survival (PFS), and dose‐adjusted adverse events.
Marc Cerou, Christine Veyrat‐Follet, Sophie Fliscounakis‐Huynh, Clemence Pouzin, Nathalie Fagniez, Frano Mihaljevic, Mustapha Chadjaa, Emmanuelle Comets, Hoai‐Thu Thai   +8 more
wiley   +1 more source

A nearly terrestrial D/H for comet 67P/Churyumov-Gerasimenko. [PDF]

Sci Adv
Mandt KE, Lustig-Yaeger J, Luspay-Kuti A, Wurz P, Bodewits D, Fuselier SA, Mousis O, Petrinec SM, Trattner KJ.   +8 more
europepmc   +1 more source

Disintegration and Skipping Dynamics of Bilobate‐Shaped Meteoroids for Generating Ultra‐Long Strewn Fields

Earth and Space Science, Volume 13, Issue 2, February 2026.
Abstract The longest known Aletai meteorite belt presents a unique phenomenon in meteoroid dynamics. To investigate its formation mechanism, this study introduces a bilobate‐shaped meteoroid model, emphasizing aerodynamic interactions and structure evolution.
Haoyu Li, Ziwen Li, Qingbo Gan, Xiangyuan Zeng   +3 more
wiley   +1 more source

Prebiotic organic compounds in samples of asteroid Bennu indicate heterogeneous aqueous alteration. [PDF]

Proc Natl Acad Sci U S A
Mojarro A, Aponte JC, Dworkin JP, Elsila JE, Glavin DP, Connolly HC, Lauretta DS.   +6 more
europepmc   +1 more source

Quantitative Characterization of Gravel Bed Structures Using 2DSSFs and Machine Learning‐Based Surrogate Surface Generation

Journal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 1, February 2026.
Abstract Accurate characterization of gravel structures is essential for understanding riverbed roughness, flow resistance, and sediment transport. However, quantifying the definitive characteristics of these gravel structures remains challenging due to the inherent complexity of particle spatial arrangement. This study presents an improved statistical
Jie Qin, Teng Wu
wiley   +1 more source

Genetic Damage to Human Lymphocytes Induced by Contaminated Water in Populations Surrounding Lake Chapala and the Santiago River, Jalisco, México. [PDF]

Toxics
Reynoso-Silva M, Alvarez-Moya C, Guzmán-Rubio FM, Velázquez-Cruz DG, Moreno-Del Río D, Ramírez-Hernández BC, Barrientos-Ramírez L, Vargas-Radillo JJ, Gutiérrez-Martínez PB, Ruíz-López MA.   +9 more
europepmc   +1 more source

What Should Be Discussed When Considering a Vaginal Birth? A Delphi Consensus Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 520-531, February 2026.
ABSTRACT Objective Spontaneous vaginal births are often the presumed choice, representing 45% of UK births. However, information about benefits and risks is inconsistently given, impacting decision‐making and experience. A Core Information Set (CIS) is an agreed set of information points discussed prior to a decision.
Andrew Demetri, Anna Davies, Danya Bakhbakhi, Alexandra Hunt, Sharea Ijaz, Sheelagh McGuinness, Gemma Beasor, Gemma Clayton, Vicky Bradley, Eve Bunni, Carol Kingdon, Andrew Sharp, Christy Burden, Asma Khalil, Louise Kenny, Abi Merriel, on behalf of the Options Collaborative Group, Deborah Lawlor, Gordon Smith, Jane Norman, Jon Heron, Dame Tina Lavender, David Lissauer, Emma McGoldrick, Simon Grant, Sherif Abdel‐Fattah, Laura Bonnet, Mairead Black, Samuel Finnikin, Amie Wilson, Alexandra Freeman, Pete Blair, Katherine Birchenall, Joanne Johnson, Abigail Johnson, Chloe de Souza, Aine Dempsey, Gabriella Snook   +37 more
wiley   +1 more source

Triple oxygen isotopes of lunar water unveil indigenous and cometary heritage. [PDF]

Proc Natl Acad Sci U S A
Thiemens MM, Martinez MHN, Thiemens MH.
europepmc   +1 more source

Verification of Hypotheses on Interstellar Comet 3I/ATLAS: Orbital Adaptation Driven by Localized Outgassing, Non-Gravitational Acceleration, and Quantum Bio-Hybrid Perspectives in Cosmic Evolution V3.0

Konishi, Hiroko
openalex   +1 more source

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source