Results 51 to 60 of about 113,206 (352)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Swift's Comet [PDF]

Science, 1880
  +10 more sources

Random walk delayed on percolation clusters [PDF]

, 2007
We study a continuous time random walk on the $d$-dimensional lattice, subject to a drift and an attraction to large clusters of a subcritical Bernoulli site percolation.
Comets, Francis, Simenhaus, Francois
core   +3 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

How Meteor Showers Can Guide the Search for Long-period Comets

The Planetary Science Journal
With orbital periods longer than 200 yr, most long-period comets (LPCs) remain undiscovered until they are in-bound toward perihelion. The comets that pass close to Earth’s orbit are potentially hazardous objects.
Samantha Hemmelgarn, Nicholas Moskovitz, Stuart Pilorz, Peter Jenniskens   +3 more
doaj   +1 more source

The Dust-to-Gas Ratio, Size Distribution, and Dust Fall-Back Fraction of Comet 67P/Churyumov-Gerasimenko: Inferences From Linking the Optical and Dynamical Properties of the Inner Comae

Frontiers in Physics, 2020
In this work, we present results that simultaneously constrain the dust size distribution, dust-to-gas ratio, fraction of dust re-deposition, and total mass production rates for comet 67P/Churyumov-Gerasimenko.
Raphael Marschall, Johannes Markkanen, Selina-Barbara Gerig, Selina-Barbara Gerig, Olga Pinzón-Rodríguez, Nicolas Thomas, Nicolas Thomas, Jong-Shinn Wu   +7 more
doaj   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Using the database of coordinates of the major planets for the numerical integration of the equations of celestial bodies motion

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
Databases of major planets coordinates are created on the basis of the numerical theory of movement of planets DE405. Numerical integration of the motion equations of small bodies of Solar system is realized using the received databanks. Extra efficiency
Vladimir P Radchenko, Dmitriy A Zausaev
doaj  

Clumpy Novel Mitochondrial Signatures in Irradiated Human Diabetic Buccal Cells: A Case Control Study

Medeniyet Medical Journal
Objective: This study aimed to determine the whole free mitochondria in type-2 diabetic buccal epithelial cells using a supravital stain called 'Janus Green B' and assess their behavior after exposure to near infrared light.
Surraj SUSAI, Mrudula CHANDRUPATLA, Sumitra SIVAKOTI, Govindrao N. KUSNENIWAR, Anand K. PYATI   +4 more
doaj   +1 more source

Photometry of cometary nuclei: Rotation rates, colours and a comparison with Kuiper Belt Objects [PDF]

, 2006
We present time-series data on Jupiter Family Comets (JFCs) 17P/Holmes, 47P/Ashbrook-Jackson and 137P/Shoemaker-Levy 2. In addition we also present results from `snap-shot' observations of comets 43P/Wolf-Harrington, 44P/Reinmuth 2, 103P/Hartley 2 and ...
A'Hearn, A'Hearn, A. Fitzsimmons, Asphaug, Boehnhardt, Britt, Brownlee, C. Snodgrass, Davidsson, Davis, Delahodde, Groussin, Harris, Howell, Hsieh, Hsieh, Hughes, Ip, Jewitt, Jewitt, Jewitt, Keller, Lacerda, Lamy, Lamy, Lamy, Landolt, Licandro, Licandro, Lowry, Lowry, Lowry, Lowry, Lowry, Luu, Luu, Ortiz, Peixinho, Pravec, Pravec, Richardson, Richardson, Russell, S. C. Lowry, Sagdeev, Schwehm, Sheppard, Snodgrass, Soderblom, Tody, Tody, Toth, Trilling, Weissman, Whipple, Whipple   +55 more
core   +3 more sources