Results 51 to 60 of about 24,316 (300)

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

open access: yesAdvanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su   +4 more
wiley   +1 more source

Comets [PDF]

open access: yes
This poster shows images of comets Hale-Bopp and Shoemaker-Levy 9. The accompanying text describes possible source regions for comets in our solar system, the behavior of comets as they approach the Sun, their possible role in the evolution of Earth, and

core   +2 more sources

Are the main belt comets, comets? [PDF]

open access: yesProceedings of the International Astronomical Union, 2009
AbstractWe present the visible spectrum of asteroid-comet transition object 133P/Elst-Pizarro (7968), the first member of the new population of objects called Main Belt Comets (Hsieh & Jewitt 2006). The spectrum was obtained with the 4.2m William Herschel Telescope at the “Roque de los Muchachos” observatory.
Javier Licandro, Humberto Campins
openaire   +1 more source

Infrared observations of faint comets [PDF]

open access: yes, 1981
Infrared observations of the periodic comets Encke, Stephan-Oterma and Chernykh indicate that the dusty component in this class of comets is not radically different from the dusty component found in nonperiodic comets.
Rieke, G.   +3 more
core  

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

open access: yesAdvanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen   +7 more
wiley   +1 more source

How Meteor Showers Can Guide the Search for Long-period Comets

open access: yesThe Planetary Science Journal
With orbital periods longer than 200 yr, most long-period comets (LPCs) remain undiscovered until they are in-bound toward perihelion. The comets that pass close to Earth’s orbit are potentially hazardous objects.
Samantha Hemmelgarn   +3 more
doaj   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng   +9 more
wiley   +1 more source

Using the database of coordinates of the major planets for the numerical integration of the equations of celestial bodies motion

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
Databases of major planets coordinates are created on the basis of the numerical theory of movement of planets DE405. Numerical integration of the motion equations of small bodies of Solar system is realized using the received databanks. Extra efficiency
Vladimir P Radchenko, Dmitriy A Zausaev
doaj  

ON THE ORIGIN OF COMETS

open access: yesChinese Journal of Space Science, 1982
Abstract The fact that comets are rich in volatile material shows that they were formed and kept for a long time in the outer, low-temperature regions of the solar system. In this paper we analyse the structure in the outer edge of the solar nebula and show that no formation zone of comets can exist there. Our view is that the comets evolved from the
null Hu Zhong-wei, null Yang Ke-zhong
openaire   +1 more source

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