Results 71 to 80 of about 78,844 (253)

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

An Update of the Paper, ‘On known and less known relations of Leonhard Euler with Poland’ (DOI: 10.4467/23921749SHS.16.005.6148)

Studia Historiae Scientiarum, 2023
In this note we publish a short letter from Leonhard Euler’s son, Johann Albrecht Euler, the Secretary of the Imperial Academy in St. Petersburg, to Marcin Poczobutt-Odlanicki, the Vilnius astronomer.
Veronika Girininkaitė, Andreas Kleinert, Roman Sznajder   +2 more
doaj   +1 more source

Observation of Comets [PDF]

Nature, 1922
Dr. Crommelin in his valuable “Comet Notes,” B.A.A. Journal, March 1922, p. 198, speaking of Reid's comet (1922 a), says “the comet must have been quite well placed for Northern observers last October and November, being of the 9th magnitude.” It seems that Mr. Reid discovered the comet only a short time before it passed out of sight.
openaire   +2 more sources

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Moorehouse's Comet [PDF]

Science, 1908
n ...
openaire   +2 more sources

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

How Meteor Showers Can Guide the Search for Long-period Comets

The Planetary Science Journal
With orbital periods longer than 200 yr, most long-period comets (LPCs) remain undiscovered until they are in-bound toward perihelion. The comets that pass close to Earth’s orbit are potentially hazardous objects.
Samantha Hemmelgarn, Nicholas Moskovitz, Stuart Pilorz, Peter Jenniskens   +3 more
doaj   +1 more source

The Dust-to-Gas Ratio, Size Distribution, and Dust Fall-Back Fraction of Comet 67P/Churyumov-Gerasimenko: Inferences From Linking the Optical and Dynamical Properties of the Inner Comae

Frontiers in Physics, 2020
In this work, we present results that simultaneously constrain the dust size distribution, dust-to-gas ratio, fraction of dust re-deposition, and total mass production rates for comet 67P/Churyumov-Gerasimenko.
Raphael Marschall, Johannes Markkanen, Selina-Barbara Gerig, Selina-Barbara Gerig, Olga Pinzón-Rodríguez, Nicolas Thomas, Nicolas Thomas, Jong-Shinn Wu   +7 more
doaj   +1 more source