Results 61 to 70 of about 314,083 (295)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Hierarchical Evolution Model of Command and Control Network Based on Hypernetwork

J of Control Science and Engineering, 2019
According to the hierarchical structure of command and control network and the characteristics of hypernetwork such as heterogeneous nodes and multiple links, a hierarchical evolution model of command and control network based on hypernetwork is ...
Yun-ming Wang, Bo Chen, Xiaoshuang Chen, Chengsheng Pan   +3 more
semanticscholar   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A Complex-valued hybrid deep learning models for automatic modulation recognition

EURASIP Journal on Advances in Signal Processing
Modulation recognition methods with real-valued deep network models fail to fully leverage the complex nature of in-phase/quadrature(I/Q) signals.
Weiwen Wang, Xia Zou, Zhisong Pan, Honghua Zhao   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Current status of information management construction and future development directions for disease prevention and control institutions in China

Zhongguo gonggong weisheng
Information management departments within Chinese Center for Disease Control and Prevention (CDC) agencies played a crucial role in the control of the novel coronavirus disease (COVID-19) pandemic, and their importance has become increasingly prominent ...
Han WEI, Xiaoyan QIU, Zimu WANG, Gaoming LI, Xuefeng LI, Jian WANG   +5 more
doaj   +1 more source

Command and Control for Managing Patient Flow

Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care, 2019
Patient flow is the movements of the patient through the healthcare system that can greatly affect quality and cost of care (Hall, Belson, Murali, & Dessouky, 2006).
Abdulrahman A Alhaider, N. Lau, Paul B. Davenport, Melanie K. Morris   +3 more
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Exposure to specific polyfluoroalkyl chemicals is associated with cardiovascular disease in US adults: a population-based study

Frontiers in Cardiovascular Medicine
BackgroundPolyfluoroalkyl chemicals (PFCs) present potential health risks due to their persistence and bioaccumulation. However, there is currently insufficient evidence regarding their impact on cardiovascular disease (CVD).
Wenwen Xiao, Guojin Jian, Fei Ma, Hong Li, Xiaohong Yang, Hengyang Zhang, Yongping Cao   +6 more
doaj   +1 more source