Results 41 to 50 of about 314,083 (295)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A noise-robust voice conversion method with controllable background sounds

Complex & Intelligent Systems
Background noises are usually treated as redundant or even harmful to voice conversion. Therefore, when converting noisy speech, a pretrained module of speech separation is usually deployed to estimate clean speech prior to the conversion.
Lele Chen, Xiongwei Zhang, Yihao Li, Meng Sun, Weiwei Chen   +4 more
doaj   +1 more source

Spatial‐temporal slowfast graph convolutional network for skeleton‐based action recognition

IET Computer Vision, 2022
In skeleton‐based action recognition, the graph convolutional network (GCN) has achieved great success. Modelling skeleton data in a suitable spatial‐temporal way and designing the adjacency matrix are crucial aspects for GCN‐based methods to capture ...
Zheng Fang, Xiongwei Zhang, Tieyong Cao, Yunfei Zheng, Meng Sun   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Minimal-Intrusion Traffic Monitoring And Analysis In Mission-Critical Communication Networks [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
A good knowledge of expected and actual traffic patterns is an essential tool for network planning, design and operation in deployed, mission-critical applications.
Alberto Domingo Ajenjo, Hermann Wietgrefe   +1 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Enhancing the Transferability of Adversarial Patch via Alternating Minimization

International Journal of Computational Intelligence Systems
Adversarial patches, a type of adversarial example, pose serious security threats to deep neural networks (DNNs) by inducing erroneous outputs. Existing gradient stabilization methods aim to stabilize the optimization direction of adversarial examples ...
Yang Wang, Lei Chen, Zhen Yang, Tieyong Cao   +3 more
doaj   +1 more source

Offline prompt reinforcement learning method based on feature extraction [PDF]

PeerJ Computer Science
Recent studies have shown that combining Transformer and conditional strategies to deal with offline reinforcement learning can bring better results.
Tianlei Yao, Xiliang Chen, Yi Yao, Weiye Huang, Zhaoyang Chen   +4 more
doaj   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source