Results 21 to 30 of about 865,139 (299)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Roman commercial networks in the eastern Pyrenees in the Late Republic and Early Empire: A cost analysis of the transport of imports and exports

Treballs d'Arqueologia, 2020
A computer model of the transport network in the eastern Pyrenees is drawn up, in association with a mathematical model of cost and speed of various means of transport and types of via.
Alan Ward Koeck
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Banking Between Florence, Venice, Buda and Dalmatia in the Fourteenth Century

Acta Histriae
This article aims to explore the co-development of financial institutions in Venice and Hungary, revealing the close link between diplomacy and government finance.
Katalin Prajda
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

L’accessibilité au commerce… quand le réseau de transport fait défaut ?

Espace populations sociétés, 2016
The increase of automobile dependence in household trips, particularly for shopping trips reinforced inequalities by increasing mobility problems access to urban resources of non-or low-owning households.
Mohamed Hani
doaj   +1 more source

THE COMMERCE OF SURGERY. [PDF]

JAMA: The Journal of the American Medical Association, 1905
"It is further to be observed that just as the self-assertion necessary to the maintenance of society against the state of nature will destroy that society if it is allowed free operation within, so the self-restraint, the essence of the ethical process, which is no less an essential condition of the existence of every polity may, by excess, become ...
openaire   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

ELECTRONIC COMMERCE CONTRACTS UNDER JORDANIAN LAW: A LEGAL PERSPECTIVE

Malaysian Journal of Syariah and Law
This study explores the legal framework governing electronic commerce contracts within the context of Jordanian Law. It examines the concept, legal nature, and distinctive characteristics of electronic contracts which are essential for determining the ...
Mohammad Al-Freihat, Shaima Al-Hussien, Hashim Balas, Ahmad Alsarayrah, Mamoon Alsmadi, Talal Aleissa, Ziad Al Wasat   +6 more
doaj   +1 more source

A Survey Using Kano Model and Road map to issues Standard Model of e-commerce Using SPLE technique [PDF]

Engineering and Technology Journal, 2017
Software Product Line Engineering (SPLE) have been widely studied by many researchers and they have been used to solve different real-world applications that have more than design. However, most (SPLEs) work well only when using standard model depends on
H. Safi, A. Abbas, S. AlBawi
doaj   +1 more source