Results 121 to 130 of about 1,258,530 (358)

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu   +15 more
wiley   +1 more source

Entrepreneurial Role Models: A New Engine for Return Migrant Worker Entrepreneurship in Rural China

open access: yesSAGE Open
The selection of entrepreneurial endeavors by return migrant workers represents a form of reverse urban-to-rural labor migration that has the potential to promote rural development and contribute to rural revitalization.
Shuoyan Lin   +3 more
doaj   +1 more source

Why is 100% Reserve Banking Inefficient? [PDF]

open access: yes
Financial crises are an important concern today. One part of the problem is banking crises, at the root of which is the bank run problem. One solution is 100% reserve banking. But this is inefficient. The reasons are, however, not obvious. The literature
Gurbachan Singh
core  

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

open access: yesAdvanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu   +13 more
wiley   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo   +7 more
wiley   +1 more source

The Effects of the Current Global Economic and Financial Crisis on the EU Budget

open access: yesTransylvanian Review of Administrative Sciences, 2013
The aim of this paper is to analyze the main effects of the current global financial and economic crisis on the European Union budget and the measures that were taken in order to support the EU member states with the purpose of limiting and counteracting
Adina DORNEAN, Andreea SANDU
doaj  

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

open access: yesAdvanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li   +6 more
wiley   +1 more source

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